PMWS: An emerging disease identified in archived porcine tissues

S. Staebler; T. Sydler; E. Buergi; K. McCullough; F. McNeilly; G. Allan; A. Pospischil

doi:10.1016/j.tvjl.2004.04.001

PMWS: An emerging disease identified in archived porcine tissues

S. Staebler^*, T. Sydler, E. Buergi, K. McCullough, F. McNeilly, G. Allan, A. Pospischil

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

Postweaning multisystemic wasting syndrome (PMWS) is a disease caused by porcine circovirus type 2 (PCV-2). The disease was present as early as 1986 in Spain, 1989 in Japan and 1993 in Thailand. In view of this, we considered it possible that the disease may also have been present in Switzerland prior to its first description in 2001. A retrospective investigation was performed on paraffin-embedded lymphoid organs and ileum from 496 pigs aged 5-13 weeks collected between 1976 and mid-2001. The sections were investigated immunohistochemically using a monoclonal antibody specific for PCV-2 capsid antigen encoded by ORF2. Virus antigen was detected in tissue samples of 39 pigs from 28 farms. The earliest positive sample originated from 1986. After 1989, positive pigs were found almost every year among the 20-40 cases investigated annually. These results indicate that PCV-2 has been present in Switzerland for some time, and at least since 1986.

Original language	English
Pages (from-to)	132-134
Number of pages	3
Journal	Veterinary Journal
Volume	170
Issue number	1
DOIs	https://doi.org/10.1016/j.tvjl.2004.04.001
Publication status	Published - Jul 2005
Externally published	Yes

Bibliographical note

Funding Information:
The authors thank the technical staff for their histological and immunohistochemical expertise, and Heidi Gerber of the IVI, Mittelhausern for preparing the monoclonal antibody. This work was funded by the Swiss Federal Veterinary Office (Project No. 1.02.04).

Copyright:
Copyright 2008 Elsevier B.V., All rights reserved.

Keywords

Immunohistochemistry
PCV-2
Pig
Postweaning multisystemic wasting syndrome
Retrospective

ASJC Scopus subject areas

Animal Science and Zoology
General Veterinary

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10.1016/j.tvjl.2004.04.001

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title = "PMWS: An emerging disease identified in archived porcine tissues",

abstract = "Postweaning multisystemic wasting syndrome (PMWS) is a disease caused by porcine circovirus type 2 (PCV-2). The disease was present as early as 1986 in Spain, 1989 in Japan and 1993 in Thailand. In view of this, we considered it possible that the disease may also have been present in Switzerland prior to its first description in 2001. A retrospective investigation was performed on paraffin-embedded lymphoid organs and ileum from 496 pigs aged 5-13 weeks collected between 1976 and mid-2001. The sections were investigated immunohistochemically using a monoclonal antibody specific for PCV-2 capsid antigen encoded by ORF2. Virus antigen was detected in tissue samples of 39 pigs from 28 farms. The earliest positive sample originated from 1986. After 1989, positive pigs were found almost every year among the 20-40 cases investigated annually. These results indicate that PCV-2 has been present in Switzerland for some time, and at least since 1986.",

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author = "S. Staebler and T. Sydler and E. Buergi and K. McCullough and F. McNeilly and G. Allan and A. Pospischil",

note = "Funding Information: The authors thank the technical staff for their histological and immunohistochemical expertise, and Heidi Gerber of the IVI, Mittelhausern for preparing the monoclonal antibody. This work was funded by the Swiss Federal Veterinary Office (Project No. 1.02.04). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.",

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language = "English",

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AU - McNeilly, F.

AU - Allan, G.

AU - Pospischil, A.

N1 - Funding Information: The authors thank the technical staff for their histological and immunohistochemical expertise, and Heidi Gerber of the IVI, Mittelhausern for preparing the monoclonal antibody. This work was funded by the Swiss Federal Veterinary Office (Project No. 1.02.04). Copyright: Copyright 2008 Elsevier B.V., All rights reserved.

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PMWS: An emerging disease identified in archived porcine tissues

Abstract

Bibliographical note

Keywords

ASJC Scopus subject areas

Access to Document

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