Polymer-Supported Gold Nanoparticle Radiosensitizers with Enhanced Cellular Uptake Efficiency and Increased Cell Death in Human Prostate Cancer Cells

Lindsey Bennie, Samir A. Belhout, Susan J. Quinn, Jonathan A. Coulter

Research output: Contribution to journalArticle

Abstract

Polymer-supported gold nanoparticles (AuNPs) show increased stability to biological and physiological conditions compared to free AuNPs. Here, we demonstrate an increase in the cellular uptake efficiency of Au by the DU145 human prostate cancer cell line for 4.5 nm AuNPs loaded onto 100 nm (13%) and 200 nm (18%) polystyrene particles compared to free AuNPs (4%). Composite formulations were well tolerated by the cell with minimal direct toxicity. Under X-ray irradiation, significant radiation dose enhancement of 1.23 at 4 Gy was observed, outperforming previously reported radiosensitization experiments using free AuNPs, demonstrating the potential application of polymer-supported AuNPs as radiosensitizers.
Original languageEnglish
JournalACS Applied Nano Materials
DOIs
Publication statusPublished - 19 Mar 2020

Fingerprint Dive into the research topics of 'Polymer-Supported Gold Nanoparticle Radiosensitizers with Enhanced Cellular Uptake Efficiency and Increased Cell Death in Human Prostate Cancer Cells'. Together they form a unique fingerprint.

  • Cite this