Polymer-Supported Gold Nanoparticle Radiosensitizers with Enhanced Cellular Uptake Efficiency and Increased Cell Death in Human Prostate Cancer Cells

Lindsey Bennie; Samir A. Belhout; Susan J. Quinn; Jonathan A. Coulter

doi:10.1021/acsanm.0c00413

Polymer-Supported Gold Nanoparticle Radiosensitizers with Enhanced Cellular Uptake Efficiency and Increased Cell Death in Human Prostate Cancer Cells

Lindsey Bennie, Samir A. Belhout, Susan J. Quinn, Jonathan A. Coulter

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

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Abstract

Polymer-supported gold nanoparticles (AuNPs) show increased stability to biological and physiological conditions compared to free AuNPs. Here, we demonstrate an increase in the cellular uptake efficiency of Au by the DU145 human prostate cancer cell line for 4.5 nm AuNPs loaded onto 100 nm (13%) and 200 nm (18%) polystyrene particles compared to free AuNPs (4%). Composite formulations were well tolerated by the cell with minimal direct toxicity. Under X-ray irradiation, significant radiation dose enhancement of 1.23 at 4 Gy was observed, outperforming previously reported radiosensitization experiments using free AuNPs, demonstrating the potential application of polymer-supported AuNPs as radiosensitizers.

Original language	English
Journal	ACS Applied Nano Materials
DOIs	https://doi.org/10.1021/acsanm.0c00413
Publication status	Published - 19 Mar 2020

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Polymer-Supported Gold Nanoparticle Radiosensitizers with Enhanced Cellular Uptake Efficiency and Increased Cell Death in Human Prostate Cancer Cells
© 2020 American Chemical Society. This work is made available online in accordance with the publisher’s policies. Please refer to any applicable terms of use of the publisher.
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title = "Polymer-Supported Gold Nanoparticle Radiosensitizers with Enhanced Cellular Uptake Efficiency and Increased Cell Death in Human Prostate Cancer Cells",

abstract = "Polymer-supported gold nanoparticles (AuNPs) show increased stability to biological and physiological conditions compared to free AuNPs. Here, we demonstrate an increase in the cellular uptake efficiency of Au by the DU145 human prostate cancer cell line for 4.5 nm AuNPs loaded onto 100 nm (13%) and 200 nm (18%) polystyrene particles compared to free AuNPs (4%). Composite formulations were well tolerated by the cell with minimal direct toxicity. Under X-ray irradiation, significant radiation dose enhancement of 1.23 at 4 Gy was observed, outperforming previously reported radiosensitization experiments using free AuNPs, demonstrating the potential application of polymer-supported AuNPs as radiosensitizers.",

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AU - Coulter, Jonathan A.

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N2 - Polymer-supported gold nanoparticles (AuNPs) show increased stability to biological and physiological conditions compared to free AuNPs. Here, we demonstrate an increase in the cellular uptake efficiency of Au by the DU145 human prostate cancer cell line for 4.5 nm AuNPs loaded onto 100 nm (13%) and 200 nm (18%) polystyrene particles compared to free AuNPs (4%). Composite formulations were well tolerated by the cell with minimal direct toxicity. Under X-ray irradiation, significant radiation dose enhancement of 1.23 at 4 Gy was observed, outperforming previously reported radiosensitization experiments using free AuNPs, demonstrating the potential application of polymer-supported AuNPs as radiosensitizers.

AB - Polymer-supported gold nanoparticles (AuNPs) show increased stability to biological and physiological conditions compared to free AuNPs. Here, we demonstrate an increase in the cellular uptake efficiency of Au by the DU145 human prostate cancer cell line for 4.5 nm AuNPs loaded onto 100 nm (13%) and 200 nm (18%) polystyrene particles compared to free AuNPs (4%). Composite formulations were well tolerated by the cell with minimal direct toxicity. Under X-ray irradiation, significant radiation dose enhancement of 1.23 at 4 Gy was observed, outperforming previously reported radiosensitization experiments using free AuNPs, demonstrating the potential application of polymer-supported AuNPs as radiosensitizers.

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Polymer-Supported Gold Nanoparticle Radiosensitizers with Enhanced Cellular Uptake Efficiency and Increased Cell Death in Human Prostate Cancer Cells

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