Polymorphisms in SLC6A4, PAH, GABRB3, and MAOB and modification of psychotic disorder features

S.E. Bergen, A.H. Fanous, D. Walsh, Francis O'Neill, K.S. Kendler

Research output: Contribution to journalArticle

30 Citations (Scopus)

Abstract

We tested four genes [phenylalanine hydroxylase (PAH), the serotonin transporter (SLC6A4), monoamine oxidase B (MAOB), and the gamma-aminobutyric acid A receptor beta-3 subunit (GABRB3)] for their impact on five schizophrenia symptom factors: delusions, hallucinations, mania, depression, and negative symptoms. In a 90 family subset of the Irish Study of High Density Schizophrenia Families, the PAH 232 bp microsatellite allele demonstrated significant association with the delusions factor using both QTDT (F = 8.0, p = .031) and QPDTPHASE (chi-square = 12.54, p = .028). Also, a significant association between the GABRB3 191 bp allele and the hallucinations factor was detected using QPDTPHASE (chi-square 15.51, p = .030), but not QTDT (chi-square = 2.07, p = .560). (C) 2009 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)94-97
Number of pages4
JournalSchizophrenia research
Volume109
Issue number1-3
DOIs
Publication statusPublished - Apr 2009

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Biological Psychiatry

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