Polymorphisms of fat mass and obesity-associated gene in the pathogenesis of child and adolescent metabolic syndrome

Yongyan Song*, Henry Wade, Bingrui Zhang, Wenhao Xu, Rongxue Wu, Shujin Li *, Qiaozhu Su*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

6 Citations (Scopus)
92 Downloads (Pure)

Abstract

Childhood metabolic syndrome (MetS) is prevalent around the world and is associated with a high likelihood of suffering from severe diseases such as cardiovascular disease later in adulthood. MetS is associated with genetic susceptibility that involves gene polymorphisms. The fat mass and obesity-associated gene (FTO) encodes an RNA N6-methyladenosine demethylase that regulates RNA stability and molecular functions. Human FTO contains genetic variants that significantly contribute to the early onset of MetS in children and adolescents. Emerging evidence has also uncovered that FTO polymorphisms in intron 1, such as rs9939609 and rs9930506 polymorphisms, are significantly associated with the development of MetS in children and adolescents. Mechanistic studies reported that FTO polymorphisms lead to aberrant expressions of FTO and the adjacent genes that promote adipogenesis and appetite and reduce steatolysis, satiety, and energy expenditure in the carriers. The present review highlights the recent observations on the key FTO polymorphisms that are associated with child and adolescent MetS with an exploration of the molecular mechanisms underlying the development of increased waist circumference, hypertension, and hyperlipidemia in child and adolescent MetS.
Original languageEnglish
Article number2643
JournalNutrients
Volume15
Issue number12
DOIs
Publication statusPublished - 06 Jun 2023

Keywords

  • Humans
  • Adolescent
  • Child
  • Metabolic Syndrome/genetics
  • Polymorphism, Single Nucleotide
  • Obesity/genetics
  • Genetic Predisposition to Disease
  • Heterozygote
  • Alpha-Ketoglutarate-Dependent Dioxygenase FTO/genetics
  • Body Mass Index

Fingerprint

Dive into the research topics of 'Polymorphisms of fat mass and obesity-associated gene in the pathogenesis of child and adolescent metabolic syndrome'. Together they form a unique fingerprint.

Cite this