Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population

R M McCormack, A P Maxwell, D Carson, C C Patterson, A Bingham, D A Savage

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19 Citations (Scopus)

Abstract

Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.
Original languageEnglish
Pages (from-to)233-5
Number of pages3
JournalGenes and Immunity
Volume2
Issue number4
DOIs
Publication statusPublished - Jun 2001

ASJC Scopus subject areas

  • Genetics
  • Immunology
  • Genetics(clinical)

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