Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population

R M McCormack; A P Maxwell; D Carson; C C Patterson; A Bingham; D A Savage

doi:10.1038/sj.gene.6363749

Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population

R M McCormack, A P Maxwell, D Carson, C C Patterson, A Bingham, D A Savage

Research output: Contribution to journal › Article › peer-review

19 Citations (Scopus)

Abstract

Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.

Original language	English
Pages (from-to)	233-5
Number of pages	3
Journal	Genes and Immunity
Volume	2
Issue number	4
DOIs	https://doi.org/10.1038/sj.gene.6363749
Publication status	Published - Jun 2001

ASJC Scopus subject areas

Genetics
Immunology
Genetics(clinical)

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title = "Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population",

abstract = "Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.",

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T1 - Possible association between CTLA4 DNA polymorphisms and early onset type 1 diabetes in a UK population

AU - McCormack, R M

AU - Maxwell, A P

AU - Carson, D

AU - Patterson, C C

AU - Bingham, A

AU - Savage, D A

PY - 2001/6

Y1 - 2001/6

N2 - Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.

AB - Linkage and association has been reported between CTLA4 DNA markers and susceptibility to type 1 diabetes in some populations, but not others. We performed case-control and family-based association studies to assess if the CTLA4 A49G and intron 1 C/T polymorphisms were associated with development of early onset type 1 diabetes in the Northern Ireland population. The distribution of A49G and C/T alleles in cases (n = 144) was similar to those observed in controls (n = 307). In contrast, significant distortions in allele transmissions from informative parents to probands were observed for both the A49G (P = 0.02) and C/T (P = 0.01) polymorphisms employing 297 nuclear families. Our results suggest that the CTLA4 gene may play a minor role in the overall genetic predisposition to type 1 diabetes in this UK population.

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DO - 10.1038/sj.gene.6363749

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