Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism

Sandra E McAllister, Homa Ashrafpour, Neil Cahoon, Ning Huang, Michael A Moses, Peter C Neligan, Christopher R Forrest, Joan E Lipa, Cho Y Pang

Research output: Contribution to journalArticlepeer-review

61 Citations (Scopus)

Abstract

We tested our hypothesis that postischemic conditioning (PostC) is effective in salvage of ischemic skeletal muscle from reperfusion injury and the mechanism involves inhibition of opening of the mitochondrial permeability transition pore (mPTP). In bilateral 8x13 cm pig latissimus dorsi muscle flaps subjected to 4 h ischemia, muscle infarction increased from 22+/-4 to 41+/-1% between 2 and 24 h reperfusion and remained unchanged at 48 (38+/-6%) and 72 (40+/-1%) h reperfusion (P
Original languageEnglish
Pages (from-to)R681-9
JournalAmerican journal of physiology. Regulatory, integrative and comparative physiology
Volume295
Issue number2
DOIs
Publication statusPublished - Aug 2008

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

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