Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism

Sandra E McAllister; Homa Ashrafpour; Neil Cahoon; Ning Huang; Michael A Moses; Peter C Neligan; Christopher R Forrest; Joan E Lipa; Cho Y Pang

doi:10.1152/ajpregu.90303.2008

Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism

Sandra E McAllister, Homa Ashrafpour, Neil Cahoon, Ning Huang, Michael A Moses, Peter C Neligan, Christopher R Forrest, Joan E Lipa, Cho Y Pang

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Article › peer-review

61 Citations (Scopus)

Abstract

We tested our hypothesis that postischemic conditioning (PostC) is effective in salvage of ischemic skeletal muscle from reperfusion injury and the mechanism involves inhibition of opening of the mitochondrial permeability transition pore (mPTP). In bilateral 8x13 cm pig latissimus dorsi muscle flaps subjected to 4 h ischemia, muscle infarction increased from 22+/-4 to 41+/-1% between 2 and 24 h reperfusion and remained unchanged at 48 (38+/-6%) and 72 (40+/-1%) h reperfusion (P

Original language	English
Pages (from-to)	R681-9
Journal	American journal of physiology. Regulatory, integrative and comparative physiology
Volume	295
Issue number	2
DOIs	https://doi.org/10.1152/ajpregu.90303.2008
Publication status	Published - Aug 2008

ASJC Scopus subject areas

Physiology
Physiology (medical)

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McAllister, S. E., Ashrafpour, H., Cahoon, N., Huang, N., Moses, M. A., Neligan, P. C., Forrest, C. R., Lipa, J. E., & Pang, C. Y. (2008). Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism. American journal of physiology. Regulatory, integrative and comparative physiology, 295(2), R681-9. https://doi.org/10.1152/ajpregu.90303.2008

McAllister, Sandra E ; Ashrafpour, Homa ; Cahoon, Neil ; Huang, Ning ; Moses, Michael A ; Neligan, Peter C ; Forrest, Christopher R ; Lipa, Joan E ; Pang, Cho Y. / Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury : efficacy and mechanism. In: American journal of physiology. Regulatory, integrative and comparative physiology. 2008 ; Vol. 295, No. 2. pp. R681-9.

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abstract = "We tested our hypothesis that postischemic conditioning (PostC) is effective in salvage of ischemic skeletal muscle from reperfusion injury and the mechanism involves inhibition of opening of the mitochondrial permeability transition pore (mPTP). In bilateral 8x13 cm pig latissimus dorsi muscle flaps subjected to 4 h ischemia, muscle infarction increased from 22+/-4 to 41+/-1% between 2 and 24 h reperfusion and remained unchanged at 48 (38+/-6%) and 72 (40+/-1%) h reperfusion (P",

author = "McAllister, {Sandra E} and Homa Ashrafpour and Neil Cahoon and Ning Huang and Moses, {Michael A} and Neligan, {Peter C} and Forrest, {Christopher R} and Lipa, {Joan E} and Pang, {Cho Y}",

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McAllister, SE, Ashrafpour, H, Cahoon, N, Huang, N, Moses, MA, Neligan, PC, Forrest, CR, Lipa, JE & Pang, CY 2008, 'Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury: efficacy and mechanism', American journal of physiology. Regulatory, integrative and comparative physiology, vol. 295, no. 2, pp. R681-9. https://doi.org/10.1152/ajpregu.90303.2008

Postconditioning for salvage of ischemic skeletal muscle from reperfusion injury : efficacy and mechanism. / McAllister, Sandra E; Ashrafpour, Homa; Cahoon, Neil; Huang, Ning; Moses, Michael A; Neligan, Peter C; Forrest, Christopher R; Lipa, Joan E; Pang, Cho Y.

In: American journal of physiology. Regulatory, integrative and comparative physiology, Vol. 295, No. 2, 08.2008, p. R681-9.

Research output: Contribution to journal › Article › peer-review

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AU - McAllister, Sandra E

AU - Ashrafpour, Homa

AU - Cahoon, Neil

AU - Huang, Ning

AU - Moses, Michael A

AU - Neligan, Peter C

AU - Forrest, Christopher R

AU - Lipa, Joan E

AU - Pang, Cho Y

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AB - We tested our hypothesis that postischemic conditioning (PostC) is effective in salvage of ischemic skeletal muscle from reperfusion injury and the mechanism involves inhibition of opening of the mitochondrial permeability transition pore (mPTP). In bilateral 8x13 cm pig latissimus dorsi muscle flaps subjected to 4 h ischemia, muscle infarction increased from 22+/-4 to 41+/-1% between 2 and 24 h reperfusion and remained unchanged at 48 (38+/-6%) and 72 (40+/-1%) h reperfusion (P

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DO - 10.1152/ajpregu.90303.2008

M3 - Article

C2 - 18509099

VL - 295

SP - R681-9

JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology

SN - 0363-6119

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