Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients

Grazia Daniela Femminella, Thalia van der Doef, Yi-Ting Wang, Eleni Frangou, Sharon Love, Valeria Calsolaro, Stefan Carver, Clive Holmes, Craig W. Ritchie, Robert M. Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben Underwood, Aparna Prasanna, Paul KorantengSalman Karim, Kehinde Junaid, Bernadette McGuinness, Anthony Peter Passmore, Ramin Nilforooshan, Ajayverma Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, John Harrison, Clive Ballard, David J. Brooks, Paul Edison

Research output: Contribution to journalMeeting abstractpeer-review


Background: Type 2 diabetes is a risk factor for Alzheimer disease (AD) and it has been demonstated that AD brain shows impaired insulin signalling. Progressive brain hypometabolism is a hallmark of AD and can be evaluated using [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). Medial temporal lobe atrophy evaluated on magnetic resonance imaging (MRI) is also a marker of neurodegeneration in AD. Peripheral insulin resistance (IR) may contribute to the etiopathogenesis of AD. Here we evaluated the association between IR, brain glucose metabolism and hippocampal volume in non-diabetic AD subjects. Method(s): 121 AD subjects form the Evaluating Liraglutide in Alzheimer's Disease (ELAD) trial (NCT01843075) were enrolled. Glucose and insulin levels were measured after a 4-hour fast on the day of the visit for the brain MRI and FDG-PET scan. Insulin resistance was calculated by the homeostatic model assessment (HOMA-IR). For [18F]FDG analysis, rCMRGlc parametric images were generated using spectral analysis with an arterial plasma input function. T1 volumetric MRI were acquired on 3T scans and automated hippocampal segmentation was done using FreeSurfer. Result(s): In this non-diabetic AD population, the prevalence of IR was about 16%. HOMA-IR was negatively correlated with the hippocampal rCMRGlc (Spearman's rho= -.232, p=.04). The correlation remained significant after correcting for age. Subjects above the cut-off value for IR (2.9) showed significant lower rCMRGlc in the hippocampus, medial temporal lobe and precentral gyrus compared to those below the cut-off. No significant correlation was observed between HOMA-IR and hippocampal volume. Conclusion(s): In this study in a non-diabetic AD population, peripheral insulin resistance correlates with reduced hippocampal glucose metabolism but not with hippocampal volume. This suggests that the peripheral insulin resistance influence AD pathology by its action on cerebral glucose metabolism and central insulin resistance.
Original languageEnglish
Pages (from-to) P736-P736
Number of pages1
JournalAlzheimers & dementia
Issue number7S, part 4
Publication statusPublished - 01 Jul 2019


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