Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients

Grazia Daniela Femminella; Thalia van der Doef; Yi-Ting Wang; Eleni Frangou; Sharon Love; Valeria Calsolaro; Stefan Carver; Clive Holmes; Craig W. Ritchie; Robert M. Lawrence; Brady McFarlane; George Tadros; Basil H. Ridha; Carol Bannister; Zuzana Walker; Hilary Archer; Elizabeth Coulthard; Ben Underwood; Aparna Prasanna; Paul Koranteng; Salman Karim; Kehinde Junaid; Bernadette McGuinness; Anthony Peter Passmore; Ramin Nilforooshan; Ajayverma Macharouthu; Andrew Donaldson; Simon Thacker; Gregor Russell; Naghma Malik; Vandana Mate; Lucy Knight; Sajeev Kshemendran; John Harrison; Clive Ballard; David J. Brooks; Paul Edison

doi:10.1016/j.jalz.2019.06.2765

Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients

Grazia Daniela Femminella, Thalia van der Doef, Yi-Ting Wang, Eleni Frangou, Sharon Love, Valeria Calsolaro, Stefan Carver, Clive Holmes, Craig W. Ritchie, Robert M. Lawrence, Brady McFarlane, George Tadros, Basil H. Ridha, Carol Bannister, Zuzana Walker, Hilary Archer, Elizabeth Coulthard, Ben Underwood, Aparna Prasanna, Paul KorantengSalman Karim, Kehinde Junaid, Bernadette McGuinness, Anthony Peter Passmore, Ramin Nilforooshan, Ajayverma Macharouthu, Andrew Donaldson, Simon Thacker, Gregor Russell, Naghma Malik, Vandana Mate, Lucy Knight, Sajeev Kshemendran, John Harrison, Clive Ballard, David J. Brooks, Paul Edison

School of Medicine, Dentistry and Biomedical Sciences

Research output: Contribution to journal › Meeting abstract › peer-review

Abstract

Background: Type 2 diabetes is a risk factor for Alzheimer disease (AD) and it has been demonstated that AD brain shows impaired insulin signalling. Progressive brain hypometabolism is a hallmark of AD and can be evaluated using [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). Medial temporal lobe atrophy evaluated on magnetic resonance imaging (MRI) is also a marker of neurodegeneration in AD. Peripheral insulin resistance (IR) may contribute to the etiopathogenesis of AD. Here we evaluated the association between IR, brain glucose metabolism and hippocampal volume in non-diabetic AD subjects. Method(s): 121 AD subjects form the Evaluating Liraglutide in Alzheimer's Disease (ELAD) trial (NCT01843075) were enrolled. Glucose and insulin levels were measured after a 4-hour fast on the day of the visit for the brain MRI and FDG-PET scan. Insulin resistance was calculated by the homeostatic model assessment (HOMA-IR). For [18F]FDG analysis, rCMRGlc parametric images were generated using spectral analysis with an arterial plasma input function. T1 volumetric MRI were acquired on 3T scans and automated hippocampal segmentation was done using FreeSurfer. Result(s): In this non-diabetic AD population, the prevalence of IR was about 16%. HOMA-IR was negatively correlated with the hippocampal rCMRGlc (Spearman's rho= -.232, p=.04). The correlation remained significant after correcting for age. Subjects above the cut-off value for IR (2.9) showed significant lower rCMRGlc in the hippocampus, medial temporal lobe and precentral gyrus compared to those below the cut-off. No significant correlation was observed between HOMA-IR and hippocampal volume. Conclusion(s): In this study in a non-diabetic AD population, peripheral insulin resistance correlates with reduced hippocampal glucose metabolism but not with hippocampal volume. This suggests that the peripheral insulin resistance influence AD pathology by its action on cerebral glucose metabolism and central insulin resistance.

Original language	English
Pages (from-to)	P736-P736
Number of pages	1
Journal	Alzheimers & dementia
Volume	15
Issue number	7S, part 4
DOIs	https://doi.org/10.1016/j.jalz.2019.06.2765
Publication status	Published - 01 Jul 2019

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10.1016/j.jalz.2019.06.2765Licence: Unspecified

Simulation of electronic and optical properties of materials for energy efficient devices
Lawrence, R. (Author), Santos, E. (Supervisor), Dec 2019
Student thesis: Doctoral Thesis › Doctor of Philosophy

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Femminella, G. D., van der Doef, T., Wang, Y.-T., Frangou, E., Love, S., Calsolaro, V., Carver, S., Holmes, C., Ritchie, C. W., Lawrence, R. M., McFarlane, B., Tadros, G., Ridha, B. H., Bannister, C., Walker, Z., Archer, H., Coulthard, E., Underwood, B., Prasanna, A., ... Edison, P. (2019). Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients. Alzheimers & dementia, 15(7S, part 4), P736-P736. https://doi.org/10.1016/j.jalz.2019.06.2765

@article{0c36553e02a04cb8bd70a80d3f978513,

title = "Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients",

abstract = "Background: Type 2 diabetes is a risk factor for Alzheimer disease (AD) and it has been demonstated that AD brain shows impaired insulin signalling. Progressive brain hypometabolism is a hallmark of AD and can be evaluated using [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). Medial temporal lobe atrophy evaluated on magnetic resonance imaging (MRI) is also a marker of neurodegeneration in AD. Peripheral insulin resistance (IR) may contribute to the etiopathogenesis of AD. Here we evaluated the association between IR, brain glucose metabolism and hippocampal volume in non-diabetic AD subjects. Method(s): 121 AD subjects form the Evaluating Liraglutide in Alzheimer's Disease (ELAD) trial (NCT01843075) were enrolled. Glucose and insulin levels were measured after a 4-hour fast on the day of the visit for the brain MRI and FDG-PET scan. Insulin resistance was calculated by the homeostatic model assessment (HOMA-IR). For [18F]FDG analysis, rCMRGlc parametric images were generated using spectral analysis with an arterial plasma input function. T1 volumetric MRI were acquired on 3T scans and automated hippocampal segmentation was done using FreeSurfer. Result(s): In this non-diabetic AD population, the prevalence of IR was about 16%. HOMA-IR was negatively correlated with the hippocampal rCMRGlc (Spearman's rho= -.232, p=.04). The correlation remained significant after correcting for age. Subjects above the cut-off value for IR (2.9) showed significant lower rCMRGlc in the hippocampus, medial temporal lobe and precentral gyrus compared to those below the cut-off. No significant correlation was observed between HOMA-IR and hippocampal volume. Conclusion(s): In this study in a non-diabetic AD population, peripheral insulin resistance correlates with reduced hippocampal glucose metabolism but not with hippocampal volume. This suggests that the peripheral insulin resistance influence AD pathology by its action on cerebral glucose metabolism and central insulin resistance.",

author = "Femminella, {Grazia Daniela} and {van der Doef}, Thalia and Yi-Ting Wang and Eleni Frangou and Sharon Love and Valeria Calsolaro and Stefan Carver and Clive Holmes and Ritchie, {Craig W.} and Lawrence, {Robert M.} and Brady McFarlane and George Tadros and Ridha, {Basil H.} and Carol Bannister and Zuzana Walker and Hilary Archer and Elizabeth Coulthard and Ben Underwood and Aparna Prasanna and Paul Koranteng and Salman Karim and Kehinde Junaid and Bernadette McGuinness and Passmore, {Anthony Peter} and Ramin Nilforooshan and Ajayverma Macharouthu and Andrew Donaldson and Simon Thacker and Gregor Russell and Naghma Malik and Vandana Mate and Lucy Knight and Sajeev Kshemendran and John Harrison and Clive Ballard and Brooks, {David J.} and Paul Edison",

year = "2019",

month = jul,

day = "1",

doi = "10.1016/j.jalz.2019.06.2765",

language = "English",

volume = "15",

pages = " P736--P736",

journal = "Alzheimers & dementia",

issn = "1552-5260",

publisher = "John Wiley & Sons Inc.",

number = "7S, part 4",

}

Femminella, GD, van der Doef, T, Wang, Y-T, Frangou, E, Love, S, Calsolaro, V, Carver, S, Holmes, C, Ritchie, CW, Lawrence, RM, McFarlane, B, Tadros, G, Ridha, BH, Bannister, C, Walker, Z, Archer, H, Coulthard, E, Underwood, B, Prasanna, A, Koranteng, P, Karim, S, Junaid, K, McGuinness, B, Passmore, AP, Nilforooshan, R, Macharouthu, A, Donaldson, A, Thacker, S, Russell, G, Malik, N, Mate, V, Knight, L, Kshemendran, S, Harrison, J, Ballard, C, Brooks, DJ & Edison, P 2019, 'Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients', Alzheimers & dementia, vol. 15, no. 7S, part 4, pp. P736-P736. https://doi.org/10.1016/j.jalz.2019.06.2765

Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients. / Femminella, Grazia Daniela; van der Doef, Thalia; Wang, Yi-Ting et al.
In: Alzheimers & dementia, Vol. 15, No. 7S, part 4, 01.07.2019, p. P736-P736.

Research output: Contribution to journal › Meeting abstract › peer-review

TY - JOUR

T1 - Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients

AU - Femminella, Grazia Daniela

AU - van der Doef, Thalia

AU - Wang, Yi-Ting

AU - Frangou, Eleni

AU - Love, Sharon

AU - Calsolaro, Valeria

AU - Carver, Stefan

AU - Holmes, Clive

AU - Ritchie, Craig W.

AU - Lawrence, Robert M.

AU - McFarlane, Brady

AU - Tadros, George

AU - Ridha, Basil H.

AU - Bannister, Carol

AU - Walker, Zuzana

AU - Archer, Hilary

AU - Coulthard, Elizabeth

AU - Underwood, Ben

AU - Prasanna, Aparna

AU - Koranteng, Paul

AU - Karim, Salman

AU - Junaid, Kehinde

AU - McGuinness, Bernadette

AU - Passmore, Anthony Peter

AU - Nilforooshan, Ramin

AU - Macharouthu, Ajayverma

AU - Donaldson, Andrew

AU - Thacker, Simon

AU - Russell, Gregor

AU - Malik, Naghma

AU - Mate, Vandana

AU - Knight, Lucy

AU - Kshemendran, Sajeev

AU - Harrison, John

AU - Ballard, Clive

AU - Brooks, David J.

AU - Edison, Paul

PY - 2019/7/1

Y1 - 2019/7/1

N2 - Background: Type 2 diabetes is a risk factor for Alzheimer disease (AD) and it has been demonstated that AD brain shows impaired insulin signalling. Progressive brain hypometabolism is a hallmark of AD and can be evaluated using [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). Medial temporal lobe atrophy evaluated on magnetic resonance imaging (MRI) is also a marker of neurodegeneration in AD. Peripheral insulin resistance (IR) may contribute to the etiopathogenesis of AD. Here we evaluated the association between IR, brain glucose metabolism and hippocampal volume in non-diabetic AD subjects. Method(s): 121 AD subjects form the Evaluating Liraglutide in Alzheimer's Disease (ELAD) trial (NCT01843075) were enrolled. Glucose and insulin levels were measured after a 4-hour fast on the day of the visit for the brain MRI and FDG-PET scan. Insulin resistance was calculated by the homeostatic model assessment (HOMA-IR). For [18F]FDG analysis, rCMRGlc parametric images were generated using spectral analysis with an arterial plasma input function. T1 volumetric MRI were acquired on 3T scans and automated hippocampal segmentation was done using FreeSurfer. Result(s): In this non-diabetic AD population, the prevalence of IR was about 16%. HOMA-IR was negatively correlated with the hippocampal rCMRGlc (Spearman's rho= -.232, p=.04). The correlation remained significant after correcting for age. Subjects above the cut-off value for IR (2.9) showed significant lower rCMRGlc in the hippocampus, medial temporal lobe and precentral gyrus compared to those below the cut-off. No significant correlation was observed between HOMA-IR and hippocampal volume. Conclusion(s): In this study in a non-diabetic AD population, peripheral insulin resistance correlates with reduced hippocampal glucose metabolism but not with hippocampal volume. This suggests that the peripheral insulin resistance influence AD pathology by its action on cerebral glucose metabolism and central insulin resistance.

AB - Background: Type 2 diabetes is a risk factor for Alzheimer disease (AD) and it has been demonstated that AD brain shows impaired insulin signalling. Progressive brain hypometabolism is a hallmark of AD and can be evaluated using [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). Medial temporal lobe atrophy evaluated on magnetic resonance imaging (MRI) is also a marker of neurodegeneration in AD. Peripheral insulin resistance (IR) may contribute to the etiopathogenesis of AD. Here we evaluated the association between IR, brain glucose metabolism and hippocampal volume in non-diabetic AD subjects. Method(s): 121 AD subjects form the Evaluating Liraglutide in Alzheimer's Disease (ELAD) trial (NCT01843075) were enrolled. Glucose and insulin levels were measured after a 4-hour fast on the day of the visit for the brain MRI and FDG-PET scan. Insulin resistance was calculated by the homeostatic model assessment (HOMA-IR). For [18F]FDG analysis, rCMRGlc parametric images were generated using spectral analysis with an arterial plasma input function. T1 volumetric MRI were acquired on 3T scans and automated hippocampal segmentation was done using FreeSurfer. Result(s): In this non-diabetic AD population, the prevalence of IR was about 16%. HOMA-IR was negatively correlated with the hippocampal rCMRGlc (Spearman's rho= -.232, p=.04). The correlation remained significant after correcting for age. Subjects above the cut-off value for IR (2.9) showed significant lower rCMRGlc in the hippocampus, medial temporal lobe and precentral gyrus compared to those below the cut-off. No significant correlation was observed between HOMA-IR and hippocampal volume. Conclusion(s): In this study in a non-diabetic AD population, peripheral insulin resistance correlates with reduced hippocampal glucose metabolism but not with hippocampal volume. This suggests that the peripheral insulin resistance influence AD pathology by its action on cerebral glucose metabolism and central insulin resistance.

U2 - 10.1016/j.jalz.2019.06.2765

DO - 10.1016/j.jalz.2019.06.2765

M3 - Meeting abstract

SN - 1552-5260

VL - 15

SP - P736-P736

JO - Alzheimers & dementia

JF - Alzheimers & dementia

IS - 7S, part 4

ER -

Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients

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Simulation of electronic and optical properties of materials for energy efficient devices

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