TY - JOUR
T1 - Poster Abstract: P2‐358: Insulin Resistance Influences Hippocampal Glucose Metabolism Rather Than Hippocampal Volume In Non-diabetic Alzheimer's Disease Patients
AU - Femminella, Grazia Daniela
AU - van der Doef, Thalia
AU - Wang, Yi-Ting
AU - Frangou, Eleni
AU - Love, Sharon
AU - Calsolaro, Valeria
AU - Carver, Stefan
AU - Holmes, Clive
AU - Ritchie, Craig W.
AU - Lawrence, Robert M.
AU - McFarlane, Brady
AU - Tadros, George
AU - Ridha, Basil H.
AU - Bannister, Carol
AU - Walker, Zuzana
AU - Archer, Hilary
AU - Coulthard, Elizabeth
AU - Underwood, Ben
AU - Prasanna, Aparna
AU - Koranteng, Paul
AU - Karim, Salman
AU - Junaid, Kehinde
AU - McGuinness, Bernadette
AU - Passmore, Anthony Peter
AU - Nilforooshan, Ramin
AU - Macharouthu, Ajayverma
AU - Donaldson, Andrew
AU - Thacker, Simon
AU - Russell, Gregor
AU - Malik, Naghma
AU - Mate, Vandana
AU - Knight, Lucy
AU - Kshemendran, Sajeev
AU - Harrison, John
AU - Ballard, Clive
AU - Brooks, David J.
AU - Edison, Paul
PY - 2019/7/1
Y1 - 2019/7/1
N2 - Background: Type 2 diabetes is a risk factor for Alzheimer disease (AD) and it has been demonstated that AD brain shows impaired insulin signalling. Progressive brain hypometabolism is a hallmark of AD and can be evaluated using [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). Medial temporal lobe atrophy evaluated on magnetic resonance imaging (MRI) is also a marker of neurodegeneration in AD. Peripheral insulin resistance (IR) may contribute to the etiopathogenesis of AD. Here we evaluated the association between IR, brain glucose metabolism and hippocampal volume in non-diabetic AD subjects. Method(s): 121 AD subjects form the Evaluating Liraglutide in Alzheimer's Disease (ELAD) trial (NCT01843075) were enrolled. Glucose and insulin levels were measured after a 4-hour fast on the day of the visit for the brain MRI and FDG-PET scan. Insulin resistance was calculated by the homeostatic model assessment (HOMA-IR). For [18F]FDG analysis, rCMRGlc parametric images were generated using spectral analysis with an arterial plasma input function. T1 volumetric MRI were acquired on 3T scans and automated hippocampal segmentation was done using FreeSurfer. Result(s): In this non-diabetic AD population, the prevalence of IR was about 16%. HOMA-IR was negatively correlated with the hippocampal rCMRGlc (Spearman's rho= -.232, p=.04). The correlation remained significant after correcting for age. Subjects above the cut-off value for IR (2.9) showed significant lower rCMRGlc in the hippocampus, medial temporal lobe and precentral gyrus compared to those below the cut-off. No significant correlation was observed between HOMA-IR and hippocampal volume. Conclusion(s): In this study in a non-diabetic AD population, peripheral insulin resistance correlates with reduced hippocampal glucose metabolism but not with hippocampal volume. This suggests that the peripheral insulin resistance influence AD pathology by its action on cerebral glucose metabolism and central insulin resistance.
AB - Background: Type 2 diabetes is a risk factor for Alzheimer disease (AD) and it has been demonstated that AD brain shows impaired insulin signalling. Progressive brain hypometabolism is a hallmark of AD and can be evaluated using [18F]-fluorodeoxyglucose (FDG) positron emission tomography (PET). Medial temporal lobe atrophy evaluated on magnetic resonance imaging (MRI) is also a marker of neurodegeneration in AD. Peripheral insulin resistance (IR) may contribute to the etiopathogenesis of AD. Here we evaluated the association between IR, brain glucose metabolism and hippocampal volume in non-diabetic AD subjects. Method(s): 121 AD subjects form the Evaluating Liraglutide in Alzheimer's Disease (ELAD) trial (NCT01843075) were enrolled. Glucose and insulin levels were measured after a 4-hour fast on the day of the visit for the brain MRI and FDG-PET scan. Insulin resistance was calculated by the homeostatic model assessment (HOMA-IR). For [18F]FDG analysis, rCMRGlc parametric images were generated using spectral analysis with an arterial plasma input function. T1 volumetric MRI were acquired on 3T scans and automated hippocampal segmentation was done using FreeSurfer. Result(s): In this non-diabetic AD population, the prevalence of IR was about 16%. HOMA-IR was negatively correlated with the hippocampal rCMRGlc (Spearman's rho= -.232, p=.04). The correlation remained significant after correcting for age. Subjects above the cut-off value for IR (2.9) showed significant lower rCMRGlc in the hippocampus, medial temporal lobe and precentral gyrus compared to those below the cut-off. No significant correlation was observed between HOMA-IR and hippocampal volume. Conclusion(s): In this study in a non-diabetic AD population, peripheral insulin resistance correlates with reduced hippocampal glucose metabolism but not with hippocampal volume. This suggests that the peripheral insulin resistance influence AD pathology by its action on cerebral glucose metabolism and central insulin resistance.
U2 - 10.1016/j.jalz.2019.06.2765
DO - 10.1016/j.jalz.2019.06.2765
M3 - Meeting abstract
VL - 15
SP - P736-P736
JO - Alzheimers & dementia
JF - Alzheimers & dementia
SN - 1552-5260
IS - 7S, part 4
ER -
