Potential roles for the PIM1 kinase in human cancer - A molecular and therapeutic appraisal

N. Shah, B. Pang, K.G. Yeoh, S. Thorn, C.S. Chen, M.B. Lilly, Manuel Salto-Tellez

Research output: Contribution to journalArticlepeer-review

117 Citations (Scopus)


In vitro experiments have shown the PIM1 kinase to have diverse biological roles in cell survival, proliferation and differentiation. In humans, PIM1 is often expressed in both normal and transformed cells. The PIM1 kinase is a true oncogene implicated in early transformation and tumour progression in haematopoietic malignancies and prostate carcinomas. it is associated with aggressive subgroups of lymphoma, is a marker of poor prognosis in prostate carcinomas and has been suggested to have a role in hormone insensitivity of prostate malignancies. PIM1 has a possible role in other carcinomas with 6p21 genomic alterations. On one hand, PIM1 (due to its role in malignancy) appears to be a promising target for drug development programmes but, on the other hand, the complexity of its molecular structure has posed challenges in the development of PIM1 inhibitors. In this review we discuss PIM1 expression in human tissues (including some new data from our laboratory), its role in human malignancies, as well as the possibilities and challenges in the development of target therapy for PIM1. (c) 2008 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)2144-2151
Number of pages8
JournalEuropean Journal of Cancer
Issue number15
Publication statusPublished - Oct 2008

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


Dive into the research topics of 'Potential roles for the PIM1 kinase in human cancer - A molecular and therapeutic appraisal'. Together they form a unique fingerprint.

Cite this