Potential strategies for the eradication of multi-drug resistant Gram-negative bacterial infections

Rawan Huwaitat, Alice P. McCloskey, Brendan F. Gilmore, Garry Laverty

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)
1212 Downloads (Pure)


Antimicrobial resistance is one of the leading threats to society. The increasing burden of multidrug-resistant Gram-negative infection is particularly concerning as such bacteria are demonstrating resistance to nearly all currently licensed therapies. Various strategies have been hypothesized to treat multidrug-resistant Gram-negative infections including: targeting the Gram-negative outer membrane; neutralization of lipopolysaccharide; inhibition of bacterial efflux pumps and prevention of protein folding. Silver and silver nanoparticles, fusogenic liposomes and nanotubes are potential strategies for extending the activity of licensed, Gram-positive selective, antibiotics to Gram-negatives. This may serve as a strategy to fill the current void in pharmaceutical development in the short term. This review outlines the most promising strategies that could be implemented to solve the threat of multidrug-resistant Gram-negative infections
Original languageEnglish
Pages (from-to)955-972
JournalFuture microbiology
Issue number7
Early online date30 Jun 2016
Publication statusPublished - Jul 2016

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