Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer

David Gonzalez, Joaquin Mateo, Albrecht Stenzinger, Federico Rojo, Michelle Shiller, Alexander W Wyatt, Frédérique Penault-Llorca, Leonard G Gomella, Ros Eeles, Anders Bjartell

Research output: Contribution to journalReview articlepeer-review

9 Downloads (Pure)

Abstract

Analysis of the genomic landscape of prostate cancer has identified different molecular subgroups with relevance for novel or existing targeted therapies. The recent approvals of the poly(ADP-ribose) polymerase (PARP) inhibitors olaparib and rucaparib in the metastatic castration-resistant prostate cancer (mCRPC) setting signal the need to embed molecular diagnostics in the clinical pathway of patients with mCRPC to identify those who can benefit from targeted therapies. Best practice guidelines in overall biospecimen collection and processing for molecular analysis are widely available for several tumour types. However, there is no standard protocol for molecular diagnostic testing in prostate cancer. Here, we provide a series of recommendations on specimen handling, sample pre-analytics, laboratory workflow, and testing pathways to maximise the success rates for clinical genomic analysis in prostate cancer. Early involvement of a multidisciplinary team of pathologists, urologists, oncologists, radiologists, nurses, molecular scientists, and laboratory staff is key to enable optimal workflow for specimen selection and preservation at the time of diagnosis so that samples are available for molecular analysis when required. Given the improved outcome of patients with mCRPC and homologous recombination repair gene alterations who have been treated with PARP inhibitors, there is an urgent need to incorporate high-quality genomic testing in the routine clinical pathway of these patients.

Original languageEnglish
JournalThe Journal of Pathology: Clinical Research
Early online date25 Feb 2021
DOIs
Publication statusEarly online date - 25 Feb 2021

Fingerprint Dive into the research topics of 'Practical considerations for optimising homologous recombination repair mutation testing in patients with metastatic prostate cancer'. Together they form a unique fingerprint.

Cite this