Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations

V. Fedirko; I. Romieu; K. Aleksandrova; T. Pischon; D. Trichopoulos; P. H. Peeters; D. Romaguera-Bosch; H. B. Bueno-de-Mesquita; C. C. Dahm; K. Overvad; M. D. Chirlaque; C. Johansen; P. E. Bidstrup; S. O. Dalton; M. J. Gunter; P. A. Wark; T. Norat; J. Halkjaer; A. Tjonneland; V. K. Dik; P. D. Siersema; M. C. Boutron-Ruault; L. Dossus; N. Bastide; T. Kuhn; R. Kaaks; H. Boeing; A. Trichopoulou; E. Klinaki; M. Katsoulis; V. Pala; S. Panico; R. Tumino; D. Palli; P. Vineis; E. Weiderpass; G. Skeie; C. A. Gonzalez; M. J. Sanchez; A. Barricarte; P. Amiano; J. R. Quiros; J. Manjer; K. Jirstrom; I. Ljuslinder; R. Palmqvist; K. T. Khaw; N. Wareham; K. E. Bradbury; M. Stepien; T. Duarte-Salles; E. Riboli; M. Jenab

doi:10.1002/ijc.28841

Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations

V. Fedirko, I. Romieu, K. Aleksandrova, T. Pischon, D. Trichopoulos, P. H. Peeters, D. Romaguera-Bosch, H. B. Bueno-de-Mesquita, C. C. Dahm, K. Overvad, M. D. Chirlaque, C. Johansen, P. E. Bidstrup, S. O. Dalton, M. J. Gunter, P. A. Wark, T. Norat, J. Halkjaer, A. Tjonneland, V. K. DikP. D. Siersema, M. C. Boutron-Ruault, L. Dossus, N. Bastide, T. Kuhn, R. Kaaks, H. Boeing, A. Trichopoulou, E. Klinaki, M. Katsoulis, V. Pala, S. Panico, R. Tumino, D. Palli, P. Vineis, E. Weiderpass, G. Skeie, C. A. Gonzalez, M. J. Sanchez, A. Barricarte, P. Amiano, J. R. Quiros, J. Manjer, K. Jirstrom, I. Ljuslinder, R. Palmqvist, K. T. Khaw, N. Wareham, K. E. Bradbury, M. Stepien, T. Duarte-Salles, E. Riboli, M. Jenab

School of Biological Sciences

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Abstract

General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre‐diagnostic anthropometric characteristics and CRC‐specific and all‐cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow‐up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre‐diagnostic BMI ≥30 kg/m2 was associated with a high risk for CRC‐specific (HR = 1.26, 95% CI = 1.04–1.52) and all‐cause (HR = 1.32, 95% CI = 1.12–1.56) death relative to BMI <25 kg/m2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC‐specific (HR = 1.10, 95% CI = 1.02–1.19) and all‐cause death (HR = 1.12, 95% CI = 1.05–1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC‐specific (HR = 1.09, 95% CI = 1.02–1.16) and all‐cause death (HR = 1.11, 95% CI = 1.05–1.18). Similar associations were observed for waist‐to‐hip and waist‐to‐height ratios. Height was not associated with CRC‐specific or all‐cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre‐diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.

Original language	Undefined/Unknown
Pages (from-to)	1949-60
Number of pages	12
Journal	International Journal of Cancer
Volume	135
Issue number	8
Early online date	13 Mar 2014
DOIs	https://doi.org/10.1002/ijc.28841
Publication status	Published - 15 Oct 2014

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Fedirko, V., Romieu, I., Aleksandrova, K., Pischon, T., Trichopoulos, D., Peeters, P. H., Romaguera-Bosch, D., Bueno-de-Mesquita, H. B., Dahm, C. C., Overvad, K., Chirlaque, M. D., Johansen, C., Bidstrup, P. E., Dalton, S. O., Gunter, M. J., Wark, P. A., Norat, T., Halkjaer, J., Tjonneland, A., ... Jenab, M. (2014). Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations. International Journal of Cancer, 135(8), 1949-60. https://doi.org/10.1002/ijc.28841

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title = "Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations",

abstract = "General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre‐diagnostic anthropometric characteristics and CRC‐specific and all‐cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow‐up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre‐diagnostic BMI ≥30 kg/m2 was associated with a high risk for CRC‐specific (HR = 1.26, 95% CI = 1.04–1.52) and all‐cause (HR = 1.32, 95% CI = 1.12–1.56) death relative to BMI <25 kg/m2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC‐specific (HR = 1.10, 95% CI = 1.02–1.19) and all‐cause death (HR = 1.12, 95% CI = 1.05–1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC‐specific (HR = 1.09, 95% CI = 1.02–1.16) and all‐cause death (HR = 1.11, 95% CI = 1.05–1.18). Similar associations were observed for waist‐to‐hip and waist‐to‐height ratios. Height was not associated with CRC‐specific or all‐cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre‐diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.",

author = "V. Fedirko and I. Romieu and K. Aleksandrova and T. Pischon and D. Trichopoulos and Peeters, {P. H.} and D. Romaguera-Bosch and Bueno-de-Mesquita, {H. B.} and Dahm, {C. C.} and K. Overvad and Chirlaque, {M. D.} and C. Johansen and Bidstrup, {P. E.} and Dalton, {S. O.} and Gunter, {M. J.} and Wark, {P. A.} and T. Norat and J. Halkjaer and A. Tjonneland and Dik, {V. K.} and Siersema, {P. D.} and Boutron-Ruault, {M. C.} and L. Dossus and N. Bastide and T. Kuhn and R. Kaaks and H. Boeing and A. Trichopoulou and E. Klinaki and M. Katsoulis and V. Pala and S. Panico and R. Tumino and D. Palli and P. Vineis and E. Weiderpass and G. Skeie and Gonzalez, {C. A.} and Sanchez, {M. J.} and A. Barricarte and P. Amiano and Quiros, {J. R.} and J. Manjer and K. Jirstrom and I. Ljuslinder and R. Palmqvist and Khaw, {K. T.} and N. Wareham and Bradbury, {K. E.} and M. Stepien and T. Duarte-Salles and E. Riboli and M. Jenab",

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volume = "135",

pages = "1949--60",

journal = "International Journal of Cancer",

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Fedirko, V, Romieu, I, Aleksandrova, K, Pischon, T, Trichopoulos, D, Peeters, PH, Romaguera-Bosch, D, Bueno-de-Mesquita, HB, Dahm, CC, Overvad, K, Chirlaque, MD, Johansen, C, Bidstrup, PE, Dalton, SO, Gunter, MJ, Wark, PA, Norat, T, Halkjaer, J, Tjonneland, A, Dik, VK, Siersema, PD, Boutron-Ruault, MC, Dossus, L, Bastide, N, Kuhn, T, Kaaks, R, Boeing, H, Trichopoulou, A, Klinaki, E, Katsoulis, M, Pala, V, Panico, S, Tumino, R, Palli, D, Vineis, P, Weiderpass, E, Skeie, G, Gonzalez, CA, Sanchez, MJ, Barricarte, A, Amiano, P, Quiros, JR, Manjer, J, Jirstrom, K, Ljuslinder, I, Palmqvist, R, Khaw, KT, Wareham, N, Bradbury, KE, Stepien, M, Duarte-Salles, T, Riboli, E & Jenab, M 2014, 'Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations', International Journal of Cancer, vol. 135, no. 8, pp. 1949-60. https://doi.org/10.1002/ijc.28841

TY - JOUR

T1 - Pre-diagnostic anthropometry and survival after colorectal cancer diagnosis in Western European populations

AU - Fedirko, V.

AU - Romieu, I.

AU - Aleksandrova, K.

AU - Pischon, T.

AU - Trichopoulos, D.

AU - Peeters, P. H.

AU - Romaguera-Bosch, D.

AU - Bueno-de-Mesquita, H. B.

AU - Dahm, C. C.

AU - Overvad, K.

AU - Chirlaque, M. D.

AU - Johansen, C.

AU - Bidstrup, P. E.

AU - Dalton, S. O.

AU - Gunter, M. J.

AU - Wark, P. A.

AU - Norat, T.

AU - Halkjaer, J.

AU - Tjonneland, A.

AU - Dik, V. K.

AU - Siersema, P. D.

AU - Boutron-Ruault, M. C.

AU - Dossus, L.

AU - Bastide, N.

AU - Kuhn, T.

AU - Kaaks, R.

AU - Boeing, H.

AU - Trichopoulou, A.

AU - Klinaki, E.

AU - Katsoulis, M.

AU - Pala, V.

AU - Panico, S.

AU - Tumino, R.

AU - Palli, D.

AU - Vineis, P.

AU - Weiderpass, E.

AU - Skeie, G.

AU - Gonzalez, C. A.

AU - Sanchez, M. J.

AU - Barricarte, A.

AU - Amiano, P.

AU - Quiros, J. R.

AU - Manjer, J.

AU - Jirstrom, K.

AU - Ljuslinder, I.

AU - Palmqvist, R.

AU - Khaw, K. T.

AU - Wareham, N.

AU - Bradbury, K. E.

AU - Stepien, M.

AU - Duarte-Salles, T.

AU - Riboli, E.

AU - Jenab, M.

PY - 2014/10/15

Y1 - 2014/10/15

N2 - General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre‐diagnostic anthropometric characteristics and CRC‐specific and all‐cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow‐up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre‐diagnostic BMI ≥30 kg/m2 was associated with a high risk for CRC‐specific (HR = 1.26, 95% CI = 1.04–1.52) and all‐cause (HR = 1.32, 95% CI = 1.12–1.56) death relative to BMI <25 kg/m2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC‐specific (HR = 1.10, 95% CI = 1.02–1.19) and all‐cause death (HR = 1.12, 95% CI = 1.05–1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC‐specific (HR = 1.09, 95% CI = 1.02–1.16) and all‐cause death (HR = 1.11, 95% CI = 1.05–1.18). Similar associations were observed for waist‐to‐hip and waist‐to‐height ratios. Height was not associated with CRC‐specific or all‐cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre‐diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.

AB - General and abdominal adiposity are associated with a high risk of developing colorectal cancer (CRC), but the role of these exposures on cancer survival has been less studied. The association between pre‐diagnostic anthropometric characteristics and CRC‐specific and all‐cause death was examined among 3,924 men and women diagnosed with CRC between 1992 and 2009 in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. Multivariable Cox proportional hazards models were used to calculate hazard ratios (HRs) and corresponding 95% confidence intervals (CIs). Over a mean follow‐up period of 49 months, 1,309 deaths occurred of which 1,043 (79.7%) were due to CRC. In multivariable analysis, pre‐diagnostic BMI ≥30 kg/m2 was associated with a high risk for CRC‐specific (HR = 1.26, 95% CI = 1.04–1.52) and all‐cause (HR = 1.32, 95% CI = 1.12–1.56) death relative to BMI <25 kg/m2. Every 5 kg/m2 increase in BMI was associated with a high risk for CRC‐specific (HR = 1.10, 95% CI = 1.02–1.19) and all‐cause death (HR = 1.12, 95% CI = 1.05–1.20); and every 10 cm increase in waist circumference was associated with a high risk for CRC‐specific (HR = 1.09, 95% CI = 1.02–1.16) and all‐cause death (HR = 1.11, 95% CI = 1.05–1.18). Similar associations were observed for waist‐to‐hip and waist‐to‐height ratios. Height was not associated with CRC‐specific or all‐cause death. Associations tended to be stronger among men than in women. Possible interactions by age at diagnosis, cancer stage, tumour location, and hormone replacement therapy use among postmenopausal women were noted. Pre‐diagnostic general and abdominal adiposity are associated with lower survival after CRC diagnosis.

U2 - 10.1002/ijc.28841

DO - 10.1002/ijc.28841

M3 - Article

SN - 0020-7136

VL - 135

SP - 1949

EP - 1960

JO - International Journal of Cancer

JF - International Journal of Cancer

IS - 8

ER -