Pre-diagnostic concordance with the WCRF/AICR guidelines and survival in European colorectal cancer patients: a cohort study

D. Romaguera, H. Ward, P. A. Wark, A. C. Vergnaud, P. H. Peeters, C. H. van Gils, P. Ferrari, V. Fedirko, M. Jenab, M. C. Boutron-Ruault, L. Dossus, L. Dartois, C. P. Hansen, C. C. Dahm, G. Buckland, M. J. Sanchez, M. Dorronsoro, C. Navarro, A. Barricarte, T. J. KeyA. Trichopoulou, C. Tsironis, P. Lagiou, G. Masala, V. Pala, R. Tumino, P. Vineis, S. Panico, H. B. Bueno-de-Mesquita, P. D. Siersema, B. Ohlsson, K. Jirstrom, M. Wennberg, L. M. Nilsson, E. Weiderpass, T. Kuhn, V. Katzke, K. T. Khaw, N. J. Wareham, A. Tjonneland, H. Boeing, J. R. Quiros, M. J. Gunter, E. Riboli, T. Norat

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Background: Cancer survivors are advised to follow lifestyle recommendations on diet, physical activity, and body fatness proposed by the World Cancer Research Fund/American Institute of Cancer Research (WCRF/AICR) for cancer prevention. Previous studies have demonstrated that higher concordance with these recommendations measured using an index score (the WCRF/AICR score) was associated with lower cancer incidence and mortality. The aim of this study was to evaluate the association between pre-diagnostic concordance with WCRF/AICR recommendations and mortality in colorectal cancer (CRC) patients. Methods: The association between the WCRF/AICR score (score range 0–6 in men and 0–7 in women; higher scores indicate greater concordance) assessed on average 6.4 years before diagnosis and CRC-specific (n = 872) and overall mortality (n = 1,113) was prospectively examined among 3,292 participants diagnosed with CRC in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort (mean follow-up time after diagnosis 4.2 years). Multivariable Cox proportional hazard models were used to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for mortality.
Original languageUndefined/Unknown
Article number107
Number of pages12
JournalBMC Medicine
Publication statusPublished - 07 May 2015

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