PREDICTION OF NETILMICIN DISPOSITION IN NEONATES

M. Darwish, M. Batayneh, J. Jenkins, M. Scott, P.S. Collier, James McElnay

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

Multiple regression analyses of data from 33 neonates who received netilmicin therapy showed that concurrent treatment with other drugs (Drg), creatinine clearance (CL(cr)), gestational age (GA), and an apgar score of less than 6 at 1 min (Agl') were significant determinants of netilmicin clearance. Apparent volume of distribution was significantly affected by postnatal age (PNA), gender, the presence of ascites and/or oedema (A/O), and whether or not the neonate was small for gestational age (SGA). The following formulae were obtained: CL (ml min-1 kg-1) = -0.108 - 0.210 (Drg) + 0.152(CL(cr)) + 0.019(GA) -0.128(Agl') (multiple R = 0.725, p
Original languageEnglish
Pages (from-to)105-118
Number of pages14
JournalBiopharmaceutics & Drug Disposition
Volume13
Publication statusPublished - 1992

Fingerprint Dive into the research topics of 'PREDICTION OF NETILMICIN DISPOSITION IN NEONATES'. Together they form a unique fingerprint.

Cite this