PREDICTION OF NETILMICIN DISPOSITION IN NEONATES

M. Darwish; M. Batayneh; J. Jenkins; M. Scott; P.S. Collier; James McElnay

PREDICTION OF NETILMICIN DISPOSITION IN NEONATES

M. Darwish, M. Batayneh, J. Jenkins, M. Scott, P.S. Collier, James McElnay

School of Pharmacy

Research output: Contribution to journal › Article › peer-review

5 Citations (Scopus)

Abstract

Multiple regression analyses of data from 33 neonates who received netilmicin therapy showed that concurrent treatment with other drugs (Drg), creatinine clearance (CL(cr)), gestational age (GA), and an apgar score of less than 6 at 1 min (Agl') were significant determinants of netilmicin clearance. Apparent volume of distribution was significantly affected by postnatal age (PNA), gender, the presence of ascites and/or oedema (A/O), and whether or not the neonate was small for gestational age (SGA). The following formulae were obtained: CL (ml min-1 kg-1) = -0.108 - 0.210 (Drg) + 0.152(CL(cr)) + 0.019(GA) -0.128(Agl') (multiple R = 0.725, p

Original language	English
Pages (from-to)	105-118
Number of pages	14
Journal	Biopharmaceutics & Drug Disposition
Volume	13
Publication status	Published - 1992

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@article{d26b42b459c84f4891adc537975d5bd1,

title = "PREDICTION OF NETILMICIN DISPOSITION IN NEONATES",

abstract = "Multiple regression analyses of data from 33 neonates who received netilmicin therapy showed that concurrent treatment with other drugs (Drg), creatinine clearance (CL(cr)), gestational age (GA), and an apgar score of less than 6 at 1 min (Agl') were significant determinants of netilmicin clearance. Apparent volume of distribution was significantly affected by postnatal age (PNA), gender, the presence of ascites and/or oedema (A/O), and whether or not the neonate was small for gestational age (SGA). The following formulae were obtained: CL (ml min-1 kg-1) = -0.108 - 0.210 (Drg) + 0.152(CL(cr)) + 0.019(GA) -0.128(Agl') (multiple R = 0.725, p",

author = "M. Darwish and M. Batayneh and J. Jenkins and M. Scott and P.S. Collier and James McElnay",

year = "1992",

language = "English",

volume = "13",

pages = "105--118",

journal = "Biopharmaceutics & Drug Disposition",

issn = "0142-2782",

publisher = "John Wiley and Sons Ltd",

}

TY - JOUR

T1 - PREDICTION OF NETILMICIN DISPOSITION IN NEONATES

AU - Darwish, M.

AU - Batayneh, M.

AU - Jenkins, J.

AU - Scott, M.

AU - Collier, P.S.

AU - McElnay, James

PY - 1992

Y1 - 1992

N2 - Multiple regression analyses of data from 33 neonates who received netilmicin therapy showed that concurrent treatment with other drugs (Drg), creatinine clearance (CL(cr)), gestational age (GA), and an apgar score of less than 6 at 1 min (Agl') were significant determinants of netilmicin clearance. Apparent volume of distribution was significantly affected by postnatal age (PNA), gender, the presence of ascites and/or oedema (A/O), and whether or not the neonate was small for gestational age (SGA). The following formulae were obtained: CL (ml min-1 kg-1) = -0.108 - 0.210 (Drg) + 0.152(CL(cr)) + 0.019(GA) -0.128(Agl') (multiple R = 0.725, p

AB - Multiple regression analyses of data from 33 neonates who received netilmicin therapy showed that concurrent treatment with other drugs (Drg), creatinine clearance (CL(cr)), gestational age (GA), and an apgar score of less than 6 at 1 min (Agl') were significant determinants of netilmicin clearance. Apparent volume of distribution was significantly affected by postnatal age (PNA), gender, the presence of ascites and/or oedema (A/O), and whether or not the neonate was small for gestational age (SGA). The following formulae were obtained: CL (ml min-1 kg-1) = -0.108 - 0.210 (Drg) + 0.152(CL(cr)) + 0.019(GA) -0.128(Agl') (multiple R = 0.725, p

M3 - Article

VL - 13

SP - 105

EP - 118

JO - Biopharmaceutics & Drug Disposition

JF - Biopharmaceutics & Drug Disposition

SN - 0142-2782

ER -