Predictive Factors for Local Control in Primary and Metastatic Lung Tumours after Four to Five Fraction Stereotactic Ablative Body Radiotherapy: A Single Institution's Comprehensive Experience

I. Thibault, I. Poon, L. Yeung, D. Erler, A. Kim, B. Keller, F. Lochray, S. Jain, H. Soliman, P. Cheung

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

AIMS: We report the outcomes of a large lung stereotactic ablative body radiotherapy (SABR) programme for primary non-small cell lung cancer (NSCLC) and pulmonary metastases. The primary study aim was to identify factors predictive for local control.

MATERIALS AND METHODS: In total, 311 pulmonary tumours in 254 patients were treated between 2008 and 2011 with SABR using 48-60 Gy in four to five fractions. Local, regional and distant failure data were collected prospectively, whereas other end points were collected retrospectively. Potential clinical and dosimetric predictors of local control were evaluated using univariate and multivariate analyses.

RESULTS: Of the 311 tumours, 240 were NSCLC and 71 were other histologies. The 2 year local control rate was 96% in stage I NSCLC, 76% in colorectal cancer (CRC) metastases and 91% in non-lung/non-CRC metastases. Predictors of better local control on multivariate analysis were non-CRC tumours and a larger proportion of the planning target volume (PTV) receiving ≥100% of the prescribed dose (higher PTV V100). Among the 45 CRC metastases, a higher PTV V100 and previous chemotherapy predicted for better local control.

CONCLUSIONS: Lung SABR of 48-60 Gy/four to five fractions resulted in high local control rates for all tumours except CRC metastases. Covering more of the PTV with the prescription dose (a higher PTV V100) also resulted in superior local control.

Original languageEnglish
Pages (from-to)713-9
Number of pages7
JournalClinical Oncology
Volume26
Issue number11
Early online date29 Jul 2014
DOIs
Publication statusPublished - Nov 2014

Keywords

  • Adenocarcinoma
  • Adenocarcinoma, Bronchiolo-Alveolar
  • Adult
  • Aged
  • Aged, 80 and over
  • Carcinoma, Large Cell
  • Carcinoma, Non-Small-Cell Lung
  • Carcinoma, Squamous Cell
  • Colorectal Neoplasms
  • Dose Fractionation
  • Female
  • Follow-Up Studies
  • Humans
  • Kidney Neoplasms
  • Lung Neoplasms
  • Male
  • Middle Aged
  • Neoplasm Recurrence, Local
  • Neoplasm Staging
  • Prognosis
  • Prospective Studies
  • Radiation Pneumonitis
  • Radiosurgery
  • Radiotherapy Planning, Computer-Assisted
  • Retrospective Studies
  • Survival Rate

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