Pregnancy Vaccination with Gold Glyco-Nanoparticles Carrying Listeria monocytogenes Peptides Protects against Listeriosis and Brain- and Cutaneous-Associated Morbidities

Ricardo Calderon-Gonzalez, Hector Teran-Navarro, Elisabet Frande-Cabanes, Eva Ferrandez-Fernandez, Javier Freire, Soledad Penades, Marco Marradi, Isabel Garcia, Jose Javier Gomez-Roman, Sonsoles Yañez-Diaz, Carmen Alvarez-Dominguez

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16 Citations (Scopus)
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Abstract

Listeriosis is a fatal infection for fetuses and newborns with two clinical main morbidities in the neonatal period, meningitis and diffused cutaneous lesions. In this study, we vaccinated pregnant females with two gold glyconanoparticles (GNP) loaded with two peptides, listeriolysin peptide 91-99 (LLO91-99) or glyceraldehyde-3-phosphate dehydrogenase 1-22 peptide (GAPDH1-22). Neonates born to vaccinated mothers were free of bacteria and healthy, while non-vaccinated mice presented clear brain affections and cutaneous diminishment of melanocytes. Therefore, these nanoparticle vaccines are effective measures to offer pregnant mothers at high risk of listeriosis interesting therapies that cross the placenta.
Original languageEnglish
Article number151
Number of pages8
JournalNanomaterials
Volume6
Issue number8
DOIs
Publication statusPublished - 19 Aug 2016
Externally publishedYes

Keywords

  • Glyconanoparticles
  • Listeria peptides
  • Vaccines
  • Melanocytes

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