This study describes the interim epidemiological findings relating to Tardive Dyskinesia for probands with schizophrenia, or poor outcome schizoaffective disorder. This sample will be genotyped for DRD3 and CYP1A2; both parents DNA is available. The study aims to collect 200 trios at completion. TD is a syndrome of abnormal involuntary movements, usually thought of as the most serious of the movement disorders resulting from neuroleptic drug-use, due to its high prevalence and potential irreversibility. The data available includes Abnormal Involuntary Movement Scale, current medication at time of assessment and age of onset of illness. Data was entered and analysed using Pin Point & SPSS. Schooler & Kane Research Criteria for Tardive Dyskinesia applied. Results of the preliminary analysis (n = 42) shows a prevalence of TD of 27.9%, in keeping with the published literature for this group of patients (20-30%, Kane & Smith, 1982). Of note 74% of probands were taking atypical neuroleptics. A significant relationship between TD and depo neuroleptic was found (P = 0.019) Although it is a relatively young population, TD shows a trend of being associated with older chronological age. Analysis of a larger group of probands is currently underway and genotyping will begin later this year.
|Number of pages||1|
|Journal||American Journal of Medical Genetics - Neuropsychiatric Genetics|
|Publication status||Published - 08 Oct 2001|
ASJC Scopus subject areas
- Psychiatry and Mental health
- Cellular and Molecular Neuroscience