Preliminary evidence of the cardiovascular effects of polysubstance misuse in nightclubs

Jon C. Cole*, H. R. Sumnall, G. W. Smith, A. Rostami-Hodjegan

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

15 Citations (Scopus)


Adverse reactions to polysubstance misuse are common in nightclubs, yet little is known of the physiological effects of polysubstance misuse in this environment. This study examined the heart rate, blood pressure and oral temperature of 50 participants recruited in a nightclub on four separate nights. In addition, the increase in environmental temperature was recorded throughout each night. There were no differences in oral temperature between polysubstance misusers (i.e. those who used Ecstasy, amphetamine, cocaine, alcohol and cannabis) and alcohol/cannabis misusers. On the other hand, there were significant differences in both heart rate and blood pressure between the two groups. These data suggest that polysubstance misusers may be at risk from cardio- and cerebrovascular toxicity. Further field/on-site work is clearly needed to investigate the effects of polysubstance misuse.

Original languageEnglish
Pages (from-to)67-70
Number of pages4
JournalJournal of Psychopharmacology
Issue number1
Publication statusPublished - 01 Jan 2005
Externally publishedYes

Bibliographical note

Open science: no


  • Alcohol
  • Blood pressure
  • Cannabis
  • Cocaine
  • Ecstasy
  • Heart rate
  • Nightclubs
  • Temperature

ASJC Scopus subject areas

  • Pharmacology
  • Psychiatry and Mental health
  • Pharmacology (medical)


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