Prenatal and postnatal inflammation in relation to cortisol levels in preterm infants at 18 months corrected age

Ayala Gover, Vann Chau, Steven P Miller, Rollin Brant, Deborah E McFadden, Kenneth J Poskitt, Anne R Synnes, Joanne Weinberg, Ruth Grunau

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Objective

To examine whether early inflammation is related to cortisol levels at 18 months corrected age (CA) in children born very preterm.

Study Design

Infants born ≤ 32 weeks gestational age were recruited in the NICU, and placental histopathology, MRI, and chart review were obtained. At 18 months CA developmental assessment and collection of 3 salivary cortisol samples were carried out. Generalized least squares was used to analyze data from 85 infants providing 222 cortisol samples.

Results

Infants exposed to chorioamnionitis with funisitis had a significantly different pattern of cortisol across the samples compared to infants with chorioamnionitis alone or no prenatal inflammation (F[4,139] = 7.3996, P <.0001). Postnatal infections, necrotizing enterocolitis and chronic lung disease were not significantly associated with the cortisol pattern at 18 months CA.

Conclusion

In children born very preterm, prenatal inflammatory stress may contribute to altered programming of the HPA axis.

Keywords: preterm, chorioamnionitis, funisitis, premature infants, hypothalamic-pituitary-adrenal axis, infection, cortisol, stress
Original languageEnglish
Pages (from-to)647-651
Number of pages5
JournalJournal of Perinatology
Volume33
Issue number8
Early online date04 Apr 2013
DOIs
Publication statusPublished - Aug 2013

Fingerprint Dive into the research topics of 'Prenatal and postnatal inflammation in relation to cortisol levels in preterm infants at 18 months corrected age'. Together they form a unique fingerprint.

  • Cite this

    Gover, A., Chau, V., Miller, S. P., Brant, R., McFadden, D. E., Poskitt, K. J., Synnes, A. R., Weinberg, J., & Grunau, R. (2013). Prenatal and postnatal inflammation in relation to cortisol levels in preterm infants at 18 months corrected age. Journal of Perinatology, 33(8), 647-651. https://doi.org/10.1038/jp.2013.24