Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Sriharsha Gupta Potta, Sriharsha Minemi, Ravi Kumar Nukala, Chairmane Peinado, Dimitrios A. Lamprou, Andrew Urquhart, D. Douroumis*

*Corresponding author for this work

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24h showing negligible cell cytotoxicity up to 15mg/mL.

Original languageEnglish
Pages (from-to)74-81
Number of pages8
JournalJournal of Microencapsulation
Volume28
Issue number1
DOIs
Publication statusPublished - 01 Feb 2011
Externally publishedYes

Keywords

  • Cytotoxicity
  • High-pressure homogenization
  • Ibuprofen
  • Solid lipid nanoparticles

ASJC Scopus subject areas

  • Pharmaceutical Science
  • Colloid and Surface Chemistry
  • Physical and Theoretical Chemistry
  • Bioengineering
  • Organic Chemistry

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