Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Sriharsha Gupta Potta; Sriharsha Minemi; Ravi Kumar Nukala; Chairmane Peinado; Dimitrios A. Lamprou; Andrew Urquhart; D. Douroumis

doi:10.3109/02652048.2010.529948

Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Sriharsha Gupta Potta, Sriharsha Minemi, Ravi Kumar Nukala, Chairmane Peinado, Dimitrios A. Lamprou, Andrew Urquhart, D. Douroumis^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

Abstract

Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24h showing negligible cell cytotoxicity up to 15mg/mL.

Original language	English
Pages (from-to)	74-81
Number of pages	8
Journal	Journal of Microencapsulation
Volume	28
Issue number	1
DOIs	https://doi.org/10.3109/02652048.2010.529948
Publication status	Published - 01 Feb 2011
Externally published	Yes

Keywords

Cytotoxicity
High-pressure homogenization
Ibuprofen
Solid lipid nanoparticles

ASJC Scopus subject areas

Pharmaceutical Science
Colloid and Surface Chemistry
Physical and Theoretical Chemistry
Bioengineering
Organic Chemistry

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title = "Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility",

abstract = "Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24h showing negligible cell cytotoxicity up to 15mg/mL.",

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author = "Potta, {Sriharsha Gupta} and Sriharsha Minemi and Nukala, {Ravi Kumar} and Chairmane Peinado and Lamprou, {Dimitrios A.} and Andrew Urquhart and D. Douroumis",

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AU - Potta, Sriharsha Gupta

AU - Minemi, Sriharsha

AU - Nukala, Ravi Kumar

AU - Peinado, Chairmane

AU - Lamprou, Dimitrios A.

AU - Urquhart, Andrew

AU - Douroumis, D.

PY - 2011/2/1

Y1 - 2011/2/1

N2 - Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24h showing negligible cell cytotoxicity up to 15mg/mL.

AB - Solid lipid nanoparticles (SLNs) loaded with ibuprofen (IBU) were prepared by solvent-free high-pressure homogenization (HPH). The produced SLNs consisted of stearic acid, triluarin or tripalmitin as lipid matrixes and various stabilizers. The produced empty and IBU-loaded SLNs were characterized for particle size stability over 8 months. Differential scanning calorimetry (DSC) and X-ray diffraction (XRD) were implemented to characterize the IBU state of freeze-dried SLNs. IBU was found to be in both amorphous and crystalline form within the lipid matrix. The lyophilized powders showed increased dissolution rates for IBU depending on the lipid nature. SLNs were incubated in Caco-2 cells for 24h showing negligible cell cytotoxicity up to 15mg/mL.

KW - Cytotoxicity

KW - High-pressure homogenization

KW - Ibuprofen

KW - Solid lipid nanoparticles

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Preparation and characterization of ibuprofen solid lipid nanoparticles with enhanced solubility

Abstract

Keywords

ASJC Scopus subject areas

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