Preparation of Cytocompatible ITO Neuroelectrodes with Enhanced Electrochemical Characteristics Using a Facile Anodic Oxidation Process

Catalina Vallejo-Giraldo, Niccolò Paolo Pampaloni, Anuradha R. Pallipurath, Parvaneh Mokarian-Tabari, John O'Connell, Justin D. Holmes, Alexandre Trotier, Katarzyna Krukiewicz, Gemma Orpella-Aceret, Eugenia Pugliese, Laura Ballerini, Michelle Kilcoyne, Eilís Dowd, Leo R. Quinlan, Abhay Pandit, Paul Kavanagh*, Manus Jonathan Paul Biggs

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)
227 Downloads (Pure)

Abstract

Physicochemical modification of implantable electrode systems is recognized as a viable strategy to enhance tissue/electrode integration and electrode performance in situ. In this work, a bench-top electrochemical process to formulate anodized indium tin oxide (ITO) films with altered roughness, conducting profiles, and thickness is explored. In addition, the influence of these anodized films on neural cell adhesion, proliferation, and function indicates that anodized ITO film cytocompatibility can be altered by varying the anodization current density. Furthermore, ITO-anodized films formed with a current density of 0.4 mA cm-2 show important primary neural cell survival, modulation of glial scar formation, and promotion of neural network activity.

Original languageEnglish
Article number1605035
Number of pages18
JournalAdvanced Functional Materials
Volume28
Issue number12
Early online date23 Mar 2017
DOIs
Publication statusEarly online date - 23 Mar 2017

Keywords

  • Cytocompatibility
  • Electrodes
  • Functionalization
  • Indium tin oxide
  • Neural interfaces

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Condensed Matter Physics
  • Electrochemistry

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