Prevalence and risk factors of retinal vein occlusionnthe Gutenberg Health Study

K A Ponto, H Elbaz, T Peto, D Laubert-Reh, H Binder, P S Wild, K Lackner, N Pfeiffer, A Mirshahi

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OBJECTIVE: To determine the age- and sex-specific prevalence and determinants of retinal vein occlusions (RVOs) in a large population-based German cohort.

METHODS: The investigation included 15,010 participants (aged 35-74 years) from the Gutenberg Health Study. We determined the prevalence of RVO (central retinal vein occlusion [CRVO] and branch retinal vein occlusion [BRVO]) for the local population by assessing fundus photographs of 12 954 (86.3%; 49.8% women and 50.2% men) participants. Further, we analyzed the associations of RVO with cardiovascular, anthropometric, and ophthalmic parameters.

RESULTS: The weighted prevalences of RVO, CRVO, and BRVO were 0.40%, 0.08%, and 0.32%, respectively. Men were 1.7 times more frequently affected by RVO than were women. Prevalence of RVO was 0.2% in participants aged 35-44 and 45-54 years, respectively, 0.48% in those aged 55-64 years, and 0.92% in those aged 65-74 years. Of persons with RVO, 91.5% had one or more cardiovascular risk factor or disease vs. 75.9% of persons without RVO. BRVO was associated with arterial hypertension (odds ratio 2.69, 95% confidence interval 1.27-5.70) and atrial fibrillation (3.37, 1.24-9.12) and CRVO with higher age (7.02, 1.63-30.19) and a family history of stroke (4.64, 1.18-18.25). Median visual acuity (base 10 logarithm of minimum angle of resolution) was 0.2 in persons with RVO vs. 0.05 in those without.

CONCLUSION: The prevalence of RVO in this German population was 0.4%, and men were 1.7 times more frequently affected than women. CRVO was associated with higher age and a family history of stroke, and BRVO was associated with arterial hypertension and atrial fibrillation.

Original languageEnglish
Pages (from-to)1254-63
JournalJournal of Thrombosis and Haemostasis
Issue number7
Publication statusPublished - Jul 2015
Externally publishedYes


  • Adult
  • Age Factors
  • Aged
  • Atrial Fibrillation
  • Female
  • Germany
  • Humans
  • Hypertension
  • Logistic Models
  • Male
  • Middle Aged
  • Odds Ratio
  • Phenotype
  • Prevalence
  • Retinal Vein Occlusion
  • Risk Factors
  • Sex Factors
  • Stroke
  • Vision Disorders
  • Visual Acuity
  • Journal Article
  • Research Support, Non-U.S. Gov't


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