Abstract
The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.
Original language | English |
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Pages (from-to) | 9601-9619 |
Number of pages | 19 |
Journal | Organic and Biomolecular Chemistry |
Volume | 10 |
Issue number | 48 |
DOIs | |
Publication status | Published - 01 Jan 2012 |