Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

R.M. Deranieh, M.L. Greenberg, P.-B. Le Calvez, M.E. Migaud, M.C. Mooney

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3 Citations (Scopus)

Abstract

The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

Original languageEnglish
Pages (from-to)9601-9619
Number of pages19
JournalOrganic and Biomolecular Chemistry
Volume10
Issue number48
DOIs
Publication statusPublished - 01 Jan 2012

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