Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

R.M. Deranieh; M.L. Greenberg; P.-B. Le Calvez; M.E. Migaud; M.C. Mooney

doi:10.1039/c2ob26577j

Probing myo-inositol 1-phosphate synthase with multisubstrate adducts

R.M. Deranieh, M.L. Greenberg, P.-B. Le Calvez, M.E. Migaud, M.C. Mooney

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

Abstract

The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

Original language	English
Pages (from-to)	9601-9619
Number of pages	19
Journal	Organic and Biomolecular Chemistry
Volume	10
Issue number	48
DOIs	https://doi.org/10.1039/c2ob26577j
Publication status	Published - 01 Jan 2012

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10.1039/c2ob26577j

Cite this

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title = "Probing myo-inositol 1-phosphate synthase with multisubstrate adducts",

abstract = "The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.",

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AU - Greenberg, M.L.

AU - Le Calvez, P.-B.

AU - Migaud, M.E.

AU - Mooney, M.C.

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AB - The synthesis of a series of carbohydrate-nucleotide hybrids, designed to be multisubstrate adducts mimicking myo-inositol 1-phosphate synthase first oxidative transition state, is reported. Their ability to inhibit the synthase has been assessed and results have been rationalised computationally to estimate their likely binding mode.

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