Process-Performance Relationships for Bioresorbable Polymers used in Bone Fixation and Tissue Scaffolds: Invited Speaker

Research output: Contribution to conferenceAbstract

Abstract

Implants made from bioresorbable polymers are gaining significant interest in orthopaedic, sports-injury and cardiovascular markets. The advantage of such materials over permanent metallic implants is that they provide temporary support during healing, then gradually degrade, transferring mechanical loads to regenerating tissue. They are also utilised in drug and bioactive release systems owing to the ability to tailor their bioresorption rate via appropriate polymer selection and post-processing procedures. Furthermore they have potential for application in patient-specific tissue scaffolds produced by layer-by-layer manufacturing techniques such as fused deposition modelling (FDM).

This presentation will review manufacturing considerations for the fabrication of bioresorbable implants, focusing on melt-processing and tissue scaffold production via fused deposition modelling. The polymers of focus will be poly lactic acid (PLA) and poly lactic-co-glycolic acid (PLGA). Furthermore post-process sterilisation strategies will be appraised with the aim of quantifying the effects of such processes and assessing the implications for performance. Typical degradation and bioactive release mechanisms will be evaluated for clinically relevant bioresorbable polymers containing bioactive fillers such as calcium carbonate, calcium phosphate and silver nanoparticles. The ability to control release profiles will be demonstrated via the application of low energy electron beam irradiation to modify the polymer’s degradation profile. Finally the benefits of in vitro degradation testing will be considered along with some of the challenges of evaluating degradable systems in vivo.
Original languageEnglish
Publication statusPublished - 12 Jan 2017
EventRSC Biomaterials Special Interest Group Annual Meeting 2017: The RSC Biomaterials Chemistry Special Interest Group - Ulster University, Belfast, United Kingdom
Duration: 11 Jan 201712 Jan 2017
http://www.rsc.org/events/detail/24301/rsc-biomaterials-special-interest-group-annual-meeting-2017

Conference

ConferenceRSC Biomaterials Special Interest Group Annual Meeting 2017
CountryUnited Kingdom
CityBelfast
Period11/01/201712/01/2017
Internet address

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    Buchanan, F. (2017). Process-Performance Relationships for Bioresorbable Polymers used in Bone Fixation and Tissue Scaffolds: Invited Speaker. Abstract from RSC Biomaterials Special Interest Group Annual Meeting 2017, Belfast, United Kingdom.