Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy

Jennifer Perais, Ridhi Agarwal, Ruth Hogg, John G. Lawrenson, Jennifer R. Evans, Yemisi Takwoingi, Noemi Lois*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

868 Downloads (Pure)


Objectives: This is a protocol for a Cochrane Review (prognosis). The objectives are as follows:. Primary objectives To assess prognostic factors for predicting the occurrence of PDR in individuals with diabetic retinopathy. Table 1. PICOTS of the primary objective (Table presented.). Secondary objectives To assess prognostic risk factors for predicting the progression of PDR from less than HRC-PDR to HRC-PDR. Table 2. PICOTS of the secondary objective (Table presented.). Investigation of sources of heterogeneity between studies We anticipate between-study heterogeneity relating to two key areas. Clinical heterogeneity including the effect of different comorbidities, medications, and interventions in study cohorts. Differences in how outcomes are measured, such as diagnoses of PDR (clinical examination versus supported by imaging/imaging technologies used) and how progression is defined. Methodological heterogeneity generated from different study designs, and how robustly studies are conducted with regard to risk of bias and approach to analysis. We will explore the effects of these aspects of heterogeneity if a meta-analysis is conducted.

Original languageEnglish
Article numberCD013775
JournalCochrane Database of Systematic Reviews
Issue number11
Publication statusPublished - 03 Nov 2020

Bibliographical note

Funding Information:
We thank Richard Fallis, Subject Librarian for Medicine, Dentistry & Biomedical Sciences at Queen's University Belfast and Iris Gordon, Cochrane Eyes and Vision (CEV) Information Specialist, for assisting with the search strategies. We thank David Owens,?Alexandra McAleenan, and Sobha Sivaprasad for their comments on this protocol. We thank Anupa Shah, Managing Editor for CEV, for her assistance throughout the editorial process.

Publisher Copyright:
Copyright © 2020 The Cochrane Collaboration. Published by John Wiley & Sons, Ltd.

Copyright 2021 Elsevier B.V., All rights reserved.

ASJC Scopus subject areas

  • Pharmacology (medical)


Dive into the research topics of 'Prognostic factors for the development and progression of proliferative diabetic retinopathy in people with diabetic retinopathy'. Together they form a unique fingerprint.

Cite this