Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes

Felicitas Thol, Haiyang Yun, Ann-Kathrin Sonntag, Frederik Damm, Eva M Weissinger, Jürgen Krauter, Katharina Wagner, Michael Morgan, Martin Wichmann, Gudrun Göhring, Gesine Bug, Oliver Ottmann, Wolf-Karsten Hofmann, Axel Schambach, Brigitte Schlegelberger, Torsten Haferlach, David Bowen, Ken Mills, Arnold Ganser, Michael Heuser

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20 Citations (Scopus)

Abstract

Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P?=?.005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P?
Original languageEnglish
Pages (from-to)1221-33
Number of pages13
JournalAnnals of Hematology
Volume91
Issue number8
DOIs
Publication statusPublished - 2012

ASJC Scopus subject areas

  • Hematology

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