Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes

Felicitas Thol; Haiyang Yun; Ann-Kathrin Sonntag; Frederik Damm; Eva M Weissinger; Jürgen Krauter; Katharina Wagner; Michael Morgan; Martin Wichmann; Gudrun Göhring; Gesine Bug; Oliver Ottmann; Wolf-Karsten Hofmann; Axel Schambach; Brigitte Schlegelberger; Torsten Haferlach; David Bowen; Ken Mills; Arnold Ganser; Michael Heuser

doi:10.1007/s00277-012-1457-7

Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes

Felicitas Thol, Haiyang Yun, Ann-Kathrin Sonntag, Frederik Damm, Eva M Weissinger, Jürgen Krauter, Katharina Wagner, Michael Morgan, Martin Wichmann, Gudrun Göhring, Gesine Bug, Oliver Ottmann, Wolf-Karsten Hofmann, Axel Schambach, Brigitte Schlegelberger, Torsten Haferlach, David Bowen, Ken Mills, Arnold Ganser, Michael Heuser

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Abstract

Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P?=?.005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P?

Original language	English
Pages (from-to)	1221-33
Number of pages	13
Journal	Annals of Hematology
Volume	91
Issue number	8
DOIs	https://doi.org/10.1007/s00277-012-1457-7
Publication status	Published - 2012

ASJC Scopus subject areas

Hematology

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Thol, F., Yun, H., Sonntag, A.-K., Damm, F., Weissinger, E. M., Krauter, J., Wagner, K., Morgan, M., Wichmann, M., Göhring, G., Bug, G., Ottmann, O., Hofmann, W.-K., Schambach, A., Schlegelberger, B., Haferlach, T., Bowen, D., Mills, K., Ganser, A., & Heuser, M. (2012). Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes. Annals of Hematology, 91(8), 1221-33. https://doi.org/10.1007/s00277-012-1457-7

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title = "Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes",

abstract = "Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P?=?.005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P?",

author = "Felicitas Thol and Haiyang Yun and Ann-Kathrin Sonntag and Frederik Damm and Weissinger, {Eva M} and J{\"u}rgen Krauter and Katharina Wagner and Michael Morgan and Martin Wichmann and Gudrun G{\"o}hring and Gesine Bug and Oliver Ottmann and Wolf-Karsten Hofmann and Axel Schambach and Brigitte Schlegelberger and Torsten Haferlach and David Bowen and Ken Mills and Arnold Ganser and Michael Heuser",

year = "2012",

doi = "10.1007/s00277-012-1457-7",

language = "English",

volume = "91",

pages = "1221--33",

journal = "Annals of Hematology",

publisher = "Springer Science and Business Media Deutschland GmbH",

number = "8",

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Thol, F, Yun, H, Sonntag, A-K, Damm, F, Weissinger, EM, Krauter, J, Wagner, K, Morgan, M, Wichmann, M, Göhring, G, Bug, G, Ottmann, O, Hofmann, W-K, Schambach, A, Schlegelberger, B, Haferlach, T, Bowen, D, Mills, K, Ganser, A & Heuser, M 2012, 'Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes', Annals of Hematology, vol. 91, no. 8, pp. 1221-33. https://doi.org/10.1007/s00277-012-1457-7

TY - JOUR

T1 - Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes

AU - Thol, Felicitas

AU - Yun, Haiyang

AU - Sonntag, Ann-Kathrin

AU - Damm, Frederik

AU - Weissinger, Eva M

AU - Krauter, Jürgen

AU - Wagner, Katharina

AU - Morgan, Michael

AU - Wichmann, Martin

AU - Göhring, Gudrun

AU - Bug, Gesine

AU - Ottmann, Oliver

AU - Hofmann, Wolf-Karsten

AU - Schambach, Axel

AU - Schlegelberger, Brigitte

AU - Haferlach, Torsten

AU - Bowen, David

AU - Mills, Ken

AU - Ganser, Arnold

AU - Heuser, Michael

PY - 2012

Y1 - 2012

N2 - Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P?=?.005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P?

AB - Overexpression of MN1, ERG, BAALC, and EVI1 (MEBE) genes in cytogenetically normal acute myeloid leukemia (AML) patients is associated with poor prognosis, but their prognostic effect in patients with myelodysplastic syndromes (MDS) has not been studied systematically. Expression data of the four genes from 140 MDS patients were combined in an additive score, which was validated in an independent patient cohort of 110 MDS patients. A high MEBE score, defined as high expression of at least two of the four genes, predicted a significantly shorter overall survival (OS) (HR 2.29, 95 % CI 1.3-4.09, P?=?.005) and time to AML progression (HR 4.83, 95 % CI 2.01-11.57, P?

U2 - 10.1007/s00277-012-1457-7

DO - 10.1007/s00277-012-1457-7

M3 - Article

C2 - 22488406

VL - 91

SP - 1221

EP - 1233

JO - Annals of Hematology

JF - Annals of Hematology

IS - 8

ER -

Prognostic significance of combined MN1, ERG, BAALC, and EVI1 (MEBE) expression in patients with myelodysplastic syndromes

Abstract

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