Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

R. Soong; N. Shah; Manuel Salto-Tellez; B.C. Tai; R.A. Soo; H.C. Han; S.S. Ng; W.L. Tan; N. Zeps; D. Joseph; R.B. Diasio; B. Iacopetta

doi:10.1093/annonc/mdm599

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

R. Soong, N. Shah, Manuel Salto-Tellez, B.C. Tai, R.A. Soo, H.C. Han, S.S. Ng, W.L. Tan, N. Zeps, D. Joseph, R.B. Diasio, B. Iacopetta

Research output: Contribution to journal › Article › peer-review

117 Citations (Scopus)

Abstract

Background: Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). It is unclear whether this occurs because such tumours have better prognosis or they are more sensitive to 5-FU treatment.

Original language	English
Pages (from-to)	915-919
Number of pages	5
Journal	Annals of Oncology
Volume	19
Issue number	5
DOIs	https://doi.org/10.1093/annonc/mdm599
Publication status	Published - May 2008

ASJC Scopus subject areas

Oncology
Cancer Research

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This output contributes to the following UN Sustainable Development Goals (SDGs)

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Soong, R., Shah, N., Salto-Tellez, M., Tai, B. C., Soo, R. A., Han, H. C., Ng, S. S., Tan, W. L., Zeps, N., Joseph, D., Diasio, R. B., & Iacopetta, B. (2008). Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy. Annals of Oncology, 19(5), 915-919. https://doi.org/10.1093/annonc/mdm599

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title = "Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy",

abstract = "Background: Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). It is unclear whether this occurs because such tumours have better prognosis or they are more sensitive to 5-FU treatment.",

author = "R. Soong and N. Shah and Manuel Salto-Tellez and B.C. Tai and R.A. Soo and H.C. Han and S.S. Ng and W.L. Tan and N. Zeps and D. Joseph and R.B. Diasio and B. Iacopetta",

year = "2008",

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language = "English",

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Soong, R, Shah, N, Salto-Tellez, M, Tai, BC, Soo, RA, Han, HC, Ng, SS, Tan, WL, Zeps, N, Joseph, D, Diasio, RB & Iacopetta, B 2008, 'Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy', Annals of Oncology, vol. 19, no. 5, pp. 915-919. https://doi.org/10.1093/annonc/mdm599

Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy. / Soong, R.; Shah, N.; Salto-Tellez, Manuel et al.
In: Annals of Oncology, Vol. 19, No. 5, 05.2008, p. 915-919.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Prognostic significance of thymidylate synthase, dihydropyrimidine dehydrogenase and thymidine phosphorylase protein expression in colorectal cancer patients treated with or without 5-fluorouracil-based chemotherapy

AU - Soong, R.

AU - Shah, N.

AU - Salto-Tellez, Manuel

AU - Tai, B.C.

AU - Soo, R.A.

AU - Han, H.C.

AU - Ng, S.S.

AU - Tan, W.L.

AU - Zeps, N.

AU - Joseph, D.

AU - Diasio, R.B.

AU - Iacopetta, B.

PY - 2008/5

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AB - Background: Low tumour expression levels of thymidylate synthase (TS), dihydropyrimidine dehydrogenase (DPD) and thymidine phosphorylase (TP) have been linked with improved outcome for colorectal cancer (CRC) patients treated with 5-fluorouracil (5-FU). It is unclear whether this occurs because such tumours have better prognosis or they are more sensitive to 5-FU treatment.

U2 - 10.1093/annonc/mdm599

DO - 10.1093/annonc/mdm599

M3 - Article

SN - 1569-8041

VL - 19

SP - 915

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JO - Annals of Oncology

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