Progress and gaps in understanding the electrophysiological properties of morphologically normal cells from the cardiac atrioventricular node.

Jules Hancox, Kathryn Yuill, John Mitcheson, Mary Convery (McGahon)

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

The atrioventricular node (AVN) is a small but critically important component of the cardiac electrical conduction system and is located at the junction between right atrium and right ventricle of the heart. It plays important roles in normal and abnormal impulse propagation. Mathematical models of the conduction properties of the AVN have been made, but detailed in silico reconstruction of AVN electrophysiology lags behind that of other cardiac regions. One important facet of detailed reconstruction of AVN electrical activity is the development of comprehensive, ionic conductance-based models of single cell electrophysiology. With a view to facilitating the construction of such models, this article reviews progress made regarding single AVN cell electrophysiological data during the last decade, predominantly focusing on that derived from morphologically normal AVN cells. Properties and potential roles of a range of currents are discussed: including L-type and T-type calcium currents (ICa,L and ICa,T respectively), background current, hyperpolarization-activated current (If), delayed and transient outward potassium currents (IKr and Ito, respectively), sodium–calcium exchanger current (INaCa), the sustained inward current (Ist) and acetylcholine-activated potassium current (IKACh).
Original languageEnglish
Pages (from-to)3675-3691
Number of pages17
JournalInternational Journal of Bifurcation and Chaos
Volume13
Issue number12
Publication statusPublished - 2003
Externally publishedYes

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Electrophysiology
Cardiac
Potassium
Cell
Vertex of a graph
Calcium
Mathematical models
Conduction
Acetylcholine
Conductance
Facet
Impulse
Mathematical Model
Propagation
Model
Range of data

Cite this

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title = "Progress and gaps in understanding the electrophysiological properties of morphologically normal cells from the cardiac atrioventricular node.",
abstract = "The atrioventricular node (AVN) is a small but critically important component of the cardiac electrical conduction system and is located at the junction between right atrium and right ventricle of the heart. It plays important roles in normal and abnormal impulse propagation. Mathematical models of the conduction properties of the AVN have been made, but detailed in silico reconstruction of AVN electrophysiology lags behind that of other cardiac regions. One important facet of detailed reconstruction of AVN electrical activity is the development of comprehensive, ionic conductance-based models of single cell electrophysiology. With a view to facilitating the construction of such models, this article reviews progress made regarding single AVN cell electrophysiological data during the last decade, predominantly focusing on that derived from morphologically normal AVN cells. Properties and potential roles of a range of currents are discussed: including L-type and T-type calcium currents (ICa,L and ICa,T respectively), background current, hyperpolarization-activated current (If), delayed and transient outward potassium currents (IKr and Ito, respectively), sodium–calcium exchanger current (INaCa), the sustained inward current (Ist) and acetylcholine-activated potassium current (IKACh).",
author = "Jules Hancox and Kathryn Yuill and John Mitcheson and {Convery (McGahon)}, Mary",
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pages = "3675--3691",
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Progress and gaps in understanding the electrophysiological properties of morphologically normal cells from the cardiac atrioventricular node. / Hancox, Jules; Yuill, Kathryn; Mitcheson, John; Convery (McGahon), Mary.

In: International Journal of Bifurcation and Chaos, Vol. 13, No. 12, 2003, p. 3675-3691.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Progress and gaps in understanding the electrophysiological properties of morphologically normal cells from the cardiac atrioventricular node.

AU - Hancox, Jules

AU - Yuill, Kathryn

AU - Mitcheson, John

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PY - 2003

Y1 - 2003

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AB - The atrioventricular node (AVN) is a small but critically important component of the cardiac electrical conduction system and is located at the junction between right atrium and right ventricle of the heart. It plays important roles in normal and abnormal impulse propagation. Mathematical models of the conduction properties of the AVN have been made, but detailed in silico reconstruction of AVN electrophysiology lags behind that of other cardiac regions. One important facet of detailed reconstruction of AVN electrical activity is the development of comprehensive, ionic conductance-based models of single cell electrophysiology. With a view to facilitating the construction of such models, this article reviews progress made regarding single AVN cell electrophysiological data during the last decade, predominantly focusing on that derived from morphologically normal AVN cells. Properties and potential roles of a range of currents are discussed: including L-type and T-type calcium currents (ICa,L and ICa,T respectively), background current, hyperpolarization-activated current (If), delayed and transient outward potassium currents (IKr and Ito, respectively), sodium–calcium exchanger current (INaCa), the sustained inward current (Ist) and acetylcholine-activated potassium current (IKACh).

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