Promoting prevention and targeting remission of asthma A EUFOREA consensus statement on raising the bar in asthma care

Milos Jesenak, Dr Anna Bobcakova, Ratko Djukanovic, Mina Gaga, Nicola A Hanania, Liam G Heaney, Ian Pavord, Santiago Quirce, Dr Dermot Ryan, Wytske Fokkens, Dr Diego Conti, Peter W Hellings, Glenis Scadding, Elizabeth Van Staeyen, Leif H Bjermer, Zuzana Diamant

Research output: Contribution to journalReview articlepeer-review

Abstract

TOPIC IMPORTANCE: Asthma is a common multifaceted respiratory disease with a major impact on quality of life. Despite increased insights into mechanisms underlying various asthma phenotypes/endotypes and the availability of targeted biologic treatment options, a substantial proportion of patients remains uncontrolled with risk of exacerbations, requiring systemic corticosteroids, and progressive disease. Current international guidelines advocate a personalized management approach to patients with uncontrolled severe asthma.

REVIEW FINDINGS: The EUFOREA asthma expert panel was convened to discuss strategies to optimize asthma care, prevent systemic corticosteroids overuse and disease progression. In this meeting report, we summarize current concepts and recommendations and provide a rationale to implement personalized asthma management at earlier stages of the disease. The ultimate goal is to move away from the current "one-size-fits-most" concept, which focuses on a symptom-driven treatment strategy, and shift towards a phenotype/endotype-targeted approach aimed at curbing the disease course by improving clinical outcomes and preserving health-related quality of life.

Original languageEnglish
JournalChest
Early online date11 Dec 2024
DOIs
Publication statusEarly online date - 11 Dec 2024

Keywords

  • Allergen immunotherapy
  • Asthma management
  • Biologics
  • Biomarkers

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