Prompt gamma-ray emission for future imaging applications in proton-boron fusion therapy

G. Petringa*, G. A.P. Cirrone, C. Caliri, G. Cuttone, L. Giuffrida, G. La Rosa, R. Manna, L. Manti, V. Marchese, C. Marchetta, D. Margarone, G. Milluzzo, A. Picciotto, F. Romano, A. D. Russo, G. Russo, D. Santonocito, V. Scuderi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

9 Citations (Scopus)


Recently, an approach exploiting the proton therapy biological enhancement by using Boron atoms injected inside a tumor, has been proposed [1-3]. Here, the 11B(p,α)2α nuclear fusion reaction channel, where three alpha particles are produced with an average energy around 4 MeV, is considered [4]. These alphas are able to penetrate the cells nucleus and strongly damage their DNA. In addition, gamma prompts emitted by the proton Boron nuclear reactions can be used for on-line proton beam imaging purposes. In this work an experimental study of the gamma prompt emissions from the proton Boron nuclear reactions has been carried out with the main aim to understand and quantify the most probable emission for future clinical applications.

Original languageEnglish
Article numberC03059
JournalJournal of Instrumentation
Issue number3
Publication statusPublished - 14 Mar 2017
Externally publishedYes


  • Instrumentation for particle-beam therapy
  • Targets (spallation source targets, radioisotope production, neutrino and muon sources)

ASJC Scopus subject areas

  • Mathematical Physics
  • Instrumentation


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