Protective and Regenerative Roles of T Cells in Central Nervous System Disorders

Research output: Contribution to journalReview article

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Abstract

Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are well-established. However, more recent studies have uncovered compelling beneficial roles of T cells in neurological diseases, ranging from tissue protection to regeneration. These divergent functions arise due to the diversity of T cell subsets, particularly CD4+ T cells. Here, we review the beneficial impact of T cell subsets in a range of neuroinflammatory and neurodegenerative diseases including multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, and CNS trauma. Both T cell-secreted mediators and direct cell contact-dependent mechanisms deliver neuroprotective, neuroregenerative and immunomodulatory signals in these settings. Understanding the molecular details of these beneficial T cell mechanisms will provide novel targets for therapeutic exploitation that can be applied to a range of neurological disorders.

Original languageEnglish
Pages (from-to)2171
JournalFrontiers in immunology
Volume10
DOIs
Publication statusPublished - 04 Sep 2019

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Central Nervous System Diseases
T-Lymphocytes
T-Lymphocyte Subsets
Nervous System Trauma
Amyotrophic Lateral Sclerosis
Nervous System Diseases
Neurodegenerative Diseases
Multiple Sclerosis
Parkinson Disease
Regeneration
Alzheimer Disease
Central Nervous System
Stroke

Bibliographical note

Copyright © 2019 Evans, Dittmer, de la Fuente and Fitzgerald.

Cite this

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title = "Protective and Regenerative Roles of T Cells in Central Nervous System Disorders",
abstract = "Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are well-established. However, more recent studies have uncovered compelling beneficial roles of T cells in neurological diseases, ranging from tissue protection to regeneration. These divergent functions arise due to the diversity of T cell subsets, particularly CD4+ T cells. Here, we review the beneficial impact of T cell subsets in a range of neuroinflammatory and neurodegenerative diseases including multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, and CNS trauma. Both T cell-secreted mediators and direct cell contact-dependent mechanisms deliver neuroprotective, neuroregenerative and immunomodulatory signals in these settings. Understanding the molecular details of these beneficial T cell mechanisms will provide novel targets for therapeutic exploitation that can be applied to a range of neurological disorders.",
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Protective and Regenerative Roles of T Cells in Central Nervous System Disorders. / Evans, Frances L; Dittmer, Marie; de la Fuente, Alerie G; Fitzgerald, Denise C.

In: Frontiers in immunology, Vol. 10, 04.09.2019, p. 2171.

Research output: Contribution to journalReview article

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AU - Evans, Frances L

AU - Dittmer, Marie

AU - de la Fuente, Alerie G

AU - Fitzgerald, Denise C

N1 - Copyright © 2019 Evans, Dittmer, de la Fuente and Fitzgerald.

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AB - Pathogenic mechanisms of T cells in several central nervous system (CNS) disorders are well-established. However, more recent studies have uncovered compelling beneficial roles of T cells in neurological diseases, ranging from tissue protection to regeneration. These divergent functions arise due to the diversity of T cell subsets, particularly CD4+ T cells. Here, we review the beneficial impact of T cell subsets in a range of neuroinflammatory and neurodegenerative diseases including multiple sclerosis, Alzheimer's disease, Parkinson's disease, amyotrophic lateral sclerosis, stroke, and CNS trauma. Both T cell-secreted mediators and direct cell contact-dependent mechanisms deliver neuroprotective, neuroregenerative and immunomodulatory signals in these settings. Understanding the molecular details of these beneficial T cell mechanisms will provide novel targets for therapeutic exploitation that can be applied to a range of neurological disorders.

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