Protein kinases C: potential targets for intervention in diabetic nephropathy

Mary Murphy, Ann McGinty, C. Godson

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

Protein kinases C are a family of serine threonine protein kinases that play key roles in extracellular signal transduction. Inappropriate activation of protein kinase C has been implicated in the pathophysiology of many diseases, including diabetes mellitus. Indeed, protein kinase C activation may contribute not only to the pathogenesis of diabetic complications such as nephropathy and retinopathy, but also to insulin resistance. Growing awareness that protein kinase C isoforms subserve specific subcellular functions has led to the development of isoform-specific inhibitors, which may be useful investigational tools and therapeutic agents for attenuating the effects of inappropriate protein kinase C activity. Here we review the role played by protein kinases C in diabetic nephropathy and the recent progress that has been made to modulate its activity using specific inhibitors. Curr Opin Nephrol Hypertens 7:563-570. (C) 1998 Lippincott Wiiliams & Wilkins.
Original languageEnglish
Pages (from-to)563-570
Number of pages8
JournalCurrent Opinion in Nephrology and Hypertension
Volume7
Issue number5
Publication statusPublished - 1998

ASJC Scopus subject areas

  • Internal Medicine
  • Nephrology

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