Protein microarrays: Challenges and promises

Anupam Talapatra, Richard Rouse, Gary Hardiman*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

78 Citations (Scopus)

Abstract

Genomics and proteomics are playing increasingly important roles as discovery tools in basic biological sciences and as diagnostic and rational therapeutic aids in the clinical arena. In recent years, high-density arrays of specified DNA sequences have gained popularity. Protein microarrays are at the forefront of this biochip revolution and promise the parallel examination of large numbers of proteins. These miniaturized arrays are currently being developed to facilitate high analytical resolution, detection sensitivity and sample throughput. Many challenges are presented by proteome scale manipulation of proteins, as there is currently no methodological equivalent to the gene chip for comparative proteomics.

Original languageEnglish
Pages (from-to)527-536
Number of pages10
JournalPharmacogenomics
Volume3
Issue number4
DOIs
Publication statusPublished - 07 Aug 2002
Externally publishedYes

Keywords

  • Antibodies
  • Comparative proteomics
  • Expression analyses
  • Protein microarrays
  • Proteome

ASJC Scopus subject areas

  • Molecular Medicine
  • Genetics
  • Pharmacology

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