Psychometrics of HRQoL questionnaires in bronchiectasis: A systematic review and meta-analysis

Rebecca H. McLeese, Arietta Spinou , Zina Alfahl, Michail Tsagris, J. Stuart Elborn, James D. Chalmers, Anthony De Soyza, Michael R. Loebinger , Surinder S. Birring, Konstantinos C. Fragkos, Robert Wilson, Katherine O'Neill, Judy M. Bradley*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

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Abstract

Introduction: Understanding the psychometric properties of health related quality of life (HRQoL) questionnaires can help inform selection in clinical trials.

Objective: To assess the psychometric properties of HRQoL questionnaires in bronchiectasis.

Methods: A literature search was conducted. HRQoL questionnaires were assessed for psychometric properties (reliability, validity, minimal clinically important difference (MCID), floor/ceiling effects). Meta-analyses assessed the associations of HRQoL with clinical measures and responsiveness of HRQoL in clinical trials.

Results: 166 studies and 12 HRQoL questionnaires were included. The BHQ, LCQ, CAT and SF-36 had good internal consistency in all domains reported (Cronbach's α≥0.7) across all studies and the QoL-B, SGRQ, CRDQ and SOLQ had good internal consistency in all domains in the majority of (but not all) studies. The BHQ, SGRQ, LCQ and CAT had good test-retest reliability in all domains reported ((intraclass correlation coefficient) ICC ≥0.7) across all studies and the QoL-B, CRDQ and SOLQ had good test-retest reliability in all domains in the majority of (but not all) studies. HRQoL questionnaires were able to discriminate between demographics, important markers of clinical status, disease severity, exacerbations and bacteriology. For HRQoL responsiveness, there was a difference between the treatment and placebo effect.

Conclusion: SGRQ was the most widely used HRQoL questionnaire in bronchiectasis studies and it had good psychometric properties, however good psychometric data are growing on bronchiectasis specific HRQoL questionnaires, QoL-B and BHQ. Future studies should focus on the medium-long term test-retest reliability, responsiveness and MCID in these HRQoL questionnaires which show potential in bronchiectasis.
Original languageEnglish
JournalEuropean Respiratory Journal
Early online date22 Apr 2021
DOIs
Publication statusEarly online date - 22 Apr 2021

Keywords

  • Bronchiectasis
  • Health-related quality of life
  • HRQoL
  • Questionnaires
  • Systematic Review
  • Non-cystic fibrosis bronchiectasis

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine
  • Respiratory Care

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