Psychosocial impact of breast/ovarian (BRCA 1/2) cancer-predictive genetic testing in a UK multi-centre clinical cohort

M. Watson, C. Foster, R. Eeles, D. Eccles, S. Ashley, R. Davidson, J. Mackay, Patrick Morrison, P. Hopwood, D.G.R. Evans

Research output: Contribution to journalArticlepeer-review

142 Citations (Scopus)

Abstract

This multi-centre UK study assesses the impact of predictive testing for breast and ovarian cancer predisposition genes (BRCA 1/2) in the clinical context. In the year following predictive testing, 261 adults (59 male) from nine UK genetics centres participated; 9 I gene mutation carriers and 170 noncarriers. Self-report questionnaires were completed at baseline (pre-genetic testing) and 1, 4 and 12 months following the genetic test result. Men were assessed for general mental health (by general health questionnaire (GHQ)) and women for general mental health, cancer-related worry, intrusive and avoidant thoughts, perception of risk and risk management behaviour. Main comparisons were between female carriers and noncarriers on all measures and men and women for general mental health. Female noncarriers benefited psychologically, with significant reductions in cancer-related worry following testing (P
Original languageEnglish
Pages (from-to)1787-1794
Number of pages8
JournalBritish Journal of Cancer
Volume91
Issue number10
DOIs
Publication statusPublished - 15 Nov 2004

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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