Pulmonary delivery of antibiotics to the lungs: current state and future prospects

Yahya H. Dallal Bashi, Rachel Mairs, Rand Murtadha, Vicky Kett

Research output: Contribution to journalArticlepeer-review

2 Downloads (Pure)

Abstract

This paper presents a comprehensive review of the current literature, clinical trials, and products approved for the delivery of antibiotics to the lungs. While there are many literature reports describing potential delivery systems, few of these have translated into marketed products. Key challenges remaining are the high doses required and, for powder formulations, the ability of the inhaler and powder combination to deliver the dose to the correct portion of the respiratory tract for maximum effect. Side effects, safety concerns, and disappointing clinical trial results remain barriers to regulatory approval. In this review, we describe some possible approaches to address these issues and highlight prospects in this area.
Original languageEnglish
Article number111
Number of pages23
JournalPharmaceutics
Volume17
Issue number1
DOIs
Publication statusPublished - 15 Jan 2025

Fingerprint

Dive into the research topics of 'Pulmonary delivery of antibiotics to the lungs: current state and future prospects'. Together they form a unique fingerprint.

Cite this