TY - JOUR
T1 - Punctal plug: a medical device to treat dry eye syndrome and for sustained drug delivery to the eye
AU - Yellepeddi, Venkata K.
AU - Sheshala, Ravi
AU - McMillan, Hannah
AU - Gujral, Chirag
AU - Jones, David
AU - Singh, Thakur Raghu Raj
PY - 2015/7
Y1 - 2015/7
N2 - Punctal plugs (PPs) are miniature medical implants that were initially developed for the treatment of dry eyes. Since their introduction in 1975, many PPs made from different materials and designs have been developed. PPs, albeit generally successful, suffer from drawbacks such as epiphora and suppurative canaliculitis. To overcome these issues intelligent designs of PPs were proposed (e.g. SmartPLUG™ and Form Fit™). PPs are also gaining interest among pharmaceutical scientists for sustaining drug delivery to the eye. This review aims to provide an overview of PPs for dry eye treatment and drug delivery to treat a range of ocular diseases. It also discusses current challenges in using PPs for ocular diseases.
AB - Punctal plugs (PPs) are miniature medical implants that were initially developed for the treatment of dry eyes. Since their introduction in 1975, many PPs made from different materials and designs have been developed. PPs, albeit generally successful, suffer from drawbacks such as epiphora and suppurative canaliculitis. To overcome these issues intelligent designs of PPs were proposed (e.g. SmartPLUG™ and Form Fit™). PPs are also gaining interest among pharmaceutical scientists for sustaining drug delivery to the eye. This review aims to provide an overview of PPs for dry eye treatment and drug delivery to treat a range of ocular diseases. It also discusses current challenges in using PPs for ocular diseases.
U2 - 10.1016/j.drudis.2015.01.013
DO - 10.1016/j.drudis.2015.01.013
M3 - Article
SN - 1359-6446
VL - 20
SP - 884
EP - 889
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 7
ER -