Purple sweet potato colour - a potential therapy for galactosemia?

David J. Timson*

*Corresponding author for this work

Research output: Contribution to journalLiterature reviewpeer-review

11 Citations (Scopus)
590 Downloads (Pure)

Abstract

Galactosemia is an inherited metabolic disease in which galactose is not properly metabolised. There are various theories to explain the molecular pathology, and recent experimental evidence strongly suggests that oxidative stress plays a key role. High galactose diets are damaging to experimental animals and oxidative stress also plays a role in this toxicity which can be alleviated by purple sweet potato colour (PSPC). This plant extract is rich in acetylated anthocyanins which have been shown to quench free radical production. The objective of this Commentary is to advance the hypothesis that PSPC, or compounds therefrom, may be a viable basis for a novel therapy for galactosemia.

Original languageEnglish
Pages (from-to)391-393
Number of pages3
JournalInternational Journal of Food sciences and Nutrition
Volume65
Issue number4
DOIs
Publication statusPublished - Jun 2014

Keywords

  • Anthocyanin
  • galactosemia
  • galactose 1-phosphate uridylyltransferase deficiency
  • inherited metabolic disease
  • oxidative stress
  • sweet potato
  • HUMAN GALACTOSE-1-PHOSPHATE URIDYLYLTRANSFERASE
  • DROSOPHILA-MELANOGASTER MODEL
  • YEAST EXPRESSION SYSTEM
  • CLASSIC GALACTOSEMIA
  • III GALACTOSEMIA
  • MOLECULAR-BIOLOGY
  • OXIDATIVE STRESS
  • I GALACTOSEMIA
  • MOUSE-LIVER
  • MUTATIONS

ASJC Scopus subject areas

  • Food Science
  • Biochemistry
  • Biochemistry, medical
  • Drug Discovery

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