Quantitative analysis of methyl and propyl parabens in neonatal DBS using LC–MS/MS

Shirish Yakkundi, Hussain Mulla, Hitesh Pandya, Mark A Turner, James McElnay

Research output: Contribution to journalArticle

5 Citations (Scopus)
1017 Downloads (Pure)

Abstract

Aim: Excipients are used to overcome the chemical, physical and microbiological challenges posed by developing formulated medicines. Both methyl and propyl paraben are commonly used in pediatric liquid formulations. There is no data on systemic exposure to parabens in neonates. The European Study of Neonatal Exposure to Excipients project has investigated this. Results & methodology: DBS sampling was used to collect opportunistic blood samples. Parabens were extracted from the DBS and analyzed using a validated LC-MS/MS assay.

Discussion & Conclusion: The above assay was applied to analyze neonatal DBS samples. The blood concentrations of parabens in neonates confirm systemic exposure to parabens following administration of routine medicines.

Original languageEnglish
Pages (from-to)1173-1182
Number of pages10
JournalBioanalysis
Volume8
Issue number11
Early online date23 May 2016
DOIs
Publication statusPublished - Jun 2016

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