Quantitative evaluation of fundus autofluorescence imaged 'in vivo' in eyes with retinal disease

N. Lois, A.S. Hatfyard, A.C. Bird, F.W. Fitzke

Research output: Contribution to journalArticle

74 Citations (Scopus)

Abstract

Aim - To describe a new method of evaluating the topographic distribution of fundus autofluorescence in eyes with retinal disease. Methods - Images of fundus autofluorescence were obtained in five patients and 34 normal volunteers using a confocal scanning laser ophthalmoscope (cSLO). To evaluate the topographic distribution of fundus autofluorescence throughout the posterior pole a rectangular box, 10 x 750 pixels, was used as the area of analysis. The box was placed, horizontally, across the macular region. The intensity of fundus autofluorescence of each pixel within the rectangular box was plotted against its degree of eccentricity. Profiles of fundus autofluorescence from patients were compared with those obtained from the age matched control group and with cSLO images. Results - Profiles of fundus autofluorescence appeared to represent the topographic distribution of fundus autofluorescence throughout the posterior pole appreciated in the cSLO images, and allowed rapid identification and quantification of areas of increased or decreased fundus autofluorescence. Conclusions - Fundus autofluorescence profiles appear to be useful to study the spatial distribution of fundus autofluorescence in eyes with retinal disease.
Original languageEnglish
Pages (from-to)741-745
Number of pages5
JournalBritish Journal of Ophthalmology
Volume84
Issue number7
DOIs
Publication statusPublished - 01 Jan 2000

Bibliographical note

MEDLINE® is the source for the MeSH terms of this document.

Fingerprint Dive into the research topics of 'Quantitative evaluation of fundus autofluorescence imaged 'in vivo' in eyes with retinal disease'. Together they form a unique fingerprint.

  • Cite this