Radiation Response in the Tumour Microenvironment: Predictive Biomarkers and Future Perspectives

Research output: Contribution to journalReview articlepeer-review

9 Downloads (Pure)

Abstract

Radiotherapy (RT) is a primary treatment modality for a number of cancers, offering potentially curative outcomes. Despite its success, tumour cells can become resistant to RT, leading to disease recurrence. Components of the tumour microenvironment (TME) likely play an integral role in managing RT success or failure including infiltrating immune cells, the tumour vasculature and stroma. Furthermore, genomic profiling of the TME could identify predictive biomarkers or gene signatures indicative of RT response. In this review, we will discuss proposed mechanisms of radioresistance within the TME, biomarkers that may predict RT outcomes, and future perspectives on radiation treatment in the era of personalised medicine.

Original languageEnglish
Article number53
Number of pages15
JournalJournal of Personalized Medicine
Volume11
Issue number1
DOIs
Publication statusPublished - 16 Jan 2021

Fingerprint Dive into the research topics of 'Radiation Response in the Tumour Microenvironment: Predictive Biomarkers and Future Perspectives'. Together they form a unique fingerprint.

Cite this