Radiobiology at ultra-high dose rates employing laser-driven ions

F. Hanton; D. Doria; K.F. Kakolee; S. Kar; S.K. Litt; H. Ahmed; C.L. Lewis; G. Nersisyan; R. Prasad; M. Zepf; M. Borghesi; F. Fiorini; D. Kirby; S. Green; J.C.G. Jeynes; K.J. Kirkby; M.J. Merchant; J. Kavanagh; K.M. Prise; G. Schettino

doi:10.1117/12.2017565

Radiobiology at ultra-high dose rates employing laser-driven ions

F. Hanton, D. Doria, K.F. Kakolee, S. Kar, S.K. Litt, H. Ahmed, C.L. Lewis, G. Nersisyan, R. Prasad, M. Zepf, M. Borghesi, F. Fiorini, D. Kirby, S. Green, J.C.G. Jeynes, K.J. Kirkby, M.J. Merchant, J. Kavanagh, K.M. Prise, G. Schettino

Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

1 Citation (Scopus)

126 Downloads (Pure)

Abstract

The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10 Gys on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4±0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source.

Original language	English
Title of host publication	Proceedings of SPIE - The International Society for Optical Engineering
Volume	8779
DOIs	https://doi.org/10.1117/12.2017565
Publication status	Published - 09 May 2013

Access to Document

10.1117/12.2017565Licence: Unspecified

Radiobiology at ultra-high dose rates employing laser-driven ionsAccepted author manuscript, 752 KBLicence: Unspecified

Cite this

Hanton, F., Doria, D., Kakolee, K. F., Kar, S., Litt, S. K., Ahmed, H., Lewis, C. L., Nersisyan, G., Prasad, R., Zepf, M., Borghesi, M., Fiorini, F., Kirby, D., Green, S., Jeynes, J. C. G., Kirkby, K. J., Merchant, M. J., Kavanagh, J., Prise, K. M., & Schettino, G. (2013). Radiobiology at ultra-high dose rates employing laser-driven ions. In Proceedings of SPIE - The International Society for Optical Engineering (Vol. 8779) https://doi.org/10.1117/12.2017565

@inproceedings{10634d0faee24cd0a5258c67ddc49d6e,

title = "Radiobiology at ultra-high dose rates employing laser-driven ions",

abstract = "The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10 Gys on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4±0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source.",

author = "F. Hanton and D. Doria and K.F. Kakolee and S. Kar and S.K. Litt and H. Ahmed and C.L. Lewis and G. Nersisyan and R. Prasad and M. Zepf and M. Borghesi and F. Fiorini and D. Kirby and S. Green and J.C.G. Jeynes and K.J. Kirkby and M.J. Merchant and J. Kavanagh and K.M. Prise and G. Schettino",

year = "2013",

month = may,

day = "9",

doi = "10.1117/12.2017565",

language = "English",

isbn = "9780819495815",

volume = "8779",

booktitle = "Proceedings of SPIE - The International Society for Optical Engineering",

}

Hanton, F, Doria, D, Kakolee, KF, Kar, S, Litt, SK, Ahmed, H, Lewis, CL, Nersisyan, G, Prasad, R, Zepf, M, Borghesi, M, Fiorini, F, Kirby, D, Green, S, Jeynes, JCG, Kirkby, KJ, Merchant, MJ, Kavanagh, J, Prise, KM & Schettino, G 2013, Radiobiology at ultra-high dose rates employing laser-driven ions. in Proceedings of SPIE - The International Society for Optical Engineering. vol. 8779. https://doi.org/10.1117/12.2017565

TY - GEN

T1 - Radiobiology at ultra-high dose rates employing laser-driven ions

AU - Hanton, F.

AU - Doria, D.

AU - Kakolee, K.F.

AU - Kar, S.

AU - Litt, S.K.

AU - Ahmed, H.

AU - Lewis, C.L.

AU - Nersisyan, G.

AU - Prasad, R.

AU - Zepf, M.

AU - Borghesi, M.

AU - Fiorini, F.

AU - Kirby, D.

AU - Green, S.

AU - Jeynes, J.C.G.

AU - Kirkby, K.J.

AU - Merchant, M.J.

AU - Kavanagh, J.

AU - Prise, K.M.

AU - Schettino, G.

PY - 2013/5/9

Y1 - 2013/5/9

N2 - The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10 Gys on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4±0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source.

AB - The potential that laser based particle accelerators offer to solve sizing and cost issues arising with conventional proton therapy has generated great interest in the understanding and development of laser ion acceleration, and in investigating the radiobiological effects induced by laser accelerated ions. Laser-driven ions are produced in bursts of ultra-short duration resulting in ultra-high dose rates, and an investigation at Queen's University Belfast was carried out to investigate this virtually unexplored regime of cell rdaiobiology. This employed the TARANIS terawatt laser producing protons in the MeV range for proton irradiation, with dose rates exceeding 10 Gys on a single exposure. A clonogenic assay was implemented to analyse the biological effect of proton irradiation on V79 cells, which, when compared to data obtained with the same cell line irradiated with conventionally accelerated protons, was found to show no significant difference. A Relative Biological effectiveness of 1.4±0.2 at 10 % Survival Fraction was estimated from a comparison with a 225 kVp X-ray source.

U2 - 10.1117/12.2017565

DO - 10.1117/12.2017565

M3 - Conference contribution

AN - SCOPUS:84880732099

SN - 9780819495815

VL - 8779

BT - Proceedings of SPIE - The International Society for Optical Engineering

ER -

Radiobiology at ultra-high dose rates employing laser-driven ions

Abstract

Access to Document

Fingerprint

Cite this