Radioisotope production using lasers: From basic science to applications

Marcia Dias Rodrigues; Aldo Bonasera; M. Scisciò; J. A. Pérez-Hernández; Michael Ehret; F. Filippi; P. L. Andreoli; M. Huault; H. Larreur; D. Singappuli; D. Molloy; Didier Raffestin; M. Alonzo; G. G. Rapisarda; Dario Lattuada; G. L. Guardo; C. Verona; Fe Consoli; Giada Petringa; A. McNamee; M. La Cognata; S. Palmerini; T. Carriere; Mattia Cipriani; G. Di Giorgio; G. Cristofari; Riccardo De Angelis; G. A. P. Cirrone; D. Margarone; Lorenzo Giuffrida; Dimitri Batani; Philippe Nicolai; K. Batani; R. Lera; VOLPE Luca; D. Giulietti; S. Agarwal; Michal Krupka; S. Singh; Fabrizio Consoli

doi:10.1063/5.0196909

Radioisotope production using lasers: From basic science to applications

Marcia Dias Rodrigues, Aldo Bonasera, M. Scisciò, J. A. Pérez-Hernández, Michael Ehret, F. Filippi, P. L. Andreoli, M. Huault, H. Larreur, D. Singappuli, D. Molloy, Didier Raffestin, M. Alonzo, G. G. Rapisarda, Dario Lattuada, G. L. Guardo, C. Verona, Fe Consoli, Giada Petringa, A. McNameeM. La Cognata, S. Palmerini, T. Carriere, Mattia Cipriani, G. Di Giorgio, G. Cristofari, Riccardo De Angelis, G. A. P. Cirrone, D. Margarone, Lorenzo Giuffrida, Dimitri Batani, Philippe Nicolai, K. Batani, R. Lera, VOLPE Luca, D. Giulietti, S. Agarwal, Michal Krupka, S. Singh, Fabrizio Consoli

School of Mathematics and Physics

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Abstract

The discovery of chirped pulse amplification has led to great improvements in laser technology, enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers. Protons with energies of tens of MeV can be accelerated using, for instance, target normal sheath acceleration and focused on secondary targets. Under such conditions, nuclear reactions can occur, with the production of radioisotopes suitable for medical application. The use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators. In this paper, we study the production of 67Cu, 63Zn, 18F, and 11C, which are currently used in positron emission tomography and other applications. At the same time, we study the reactions 10B(p,α)7Be and 70Zn(p,4n)67Ga to put further constraints on the proton distributions at different angles, as well as the reaction 11B(p,α)8Be relevant for energy production. The experiment was performed at the 1 PW laser facility at Vega III in Salamanca, Spain. Angular distributions of radioisotopes in the forward (with respect to the laser direction) and backward directions were measured using a high purity germanium detector. Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera [Nucl. Instrum. Methods Phys. Res., Sect. A 637, 164–170 (2011)].

Original language	English
Article number	037203
Number of pages	15
Journal	Matter and Radiation at Extremes
Volume	9
Issue number	3
Early online date	20 Mar 2024
DOIs	https://doi.org/10.1063/5.0196909
Publication status	Published - 01 May 2024

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Radioisotope production using lasers: From basic science to applications
Copyright 2024 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 12.8 MBLicence: CC BY

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Rodrigues, M. D., Bonasera, A., Scisciò, M., Pérez-Hernández, J. A., Ehret, M., Filippi, F., Andreoli, P. L., Huault, M., Larreur, H., Singappuli, D., Molloy, D., Raffestin, D., Alonzo, M., Rapisarda, G. G., Lattuada, D., Guardo, G. L., Verona, C., Consoli, F., Petringa, G., ... Consoli, F. (2024). Radioisotope production using lasers: From basic science to applications. Matter and Radiation at Extremes, 9(3), Article 037203. https://doi.org/10.1063/5.0196909

@article{2a7fe3e1dfbb4d499a35b53764f15459,

title = "Radioisotope production using lasers: From basic science to applications",

abstract = "The discovery of chirped pulse amplification has led to great improvements in laser technology, enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers. Protons with energies of tens of MeV can be accelerated using, for instance, target normal sheath acceleration and focused on secondary targets. Under such conditions, nuclear reactions can occur, with the production of radioisotopes suitable for medical application. The use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators. In this paper, we study the production of 67Cu, 63Zn, 18F, and 11C, which are currently used in positron emission tomography and other applications. At the same time, we study the reactions 10B(p,α)7Be and 70Zn(p,4n)67Ga to put further constraints on the proton distributions at different angles, as well as the reaction 11B(p,α)8Be relevant for energy production. The experiment was performed at the 1 PW laser facility at Vega III in Salamanca, Spain. Angular distributions of radioisotopes in the forward (with respect to the laser direction) and backward directions were measured using a high purity germanium detector. Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera [Nucl. Instrum. Methods Phys. Res., Sect. A 637, 164–170 (2011)].",

author = "Rodrigues, {Marcia Dias} and Aldo Bonasera and M. Scisci{\`o} and P{\'e}rez-Hern{\'a}ndez, {J. A.} and Michael Ehret and F. Filippi and Andreoli, {P. L.} and M. Huault and H. Larreur and D. Singappuli and D. Molloy and Didier Raffestin and M. Alonzo and Rapisarda, {G. G.} and Dario Lattuada and Guardo, {G. L.} and C. Verona and Fe Consoli and Giada Petringa and A. McNamee and Cognata, {M. La} and S. Palmerini and T. Carriere and Mattia Cipriani and Giorgio, {G. Di} and G. Cristofari and Angelis, {Riccardo De} and Cirrone, {G. A. P.} and D. Margarone and Lorenzo Giuffrida and Dimitri Batani and Philippe Nicolai and K. Batani and R. Lera and VOLPE Luca and D. Giulietti and S. Agarwal and Michal Krupka and S. Singh and Fabrizio Consoli",

year = "2024",

month = may,

day = "1",

doi = "10.1063/5.0196909",

language = "English",

volume = "9",

journal = "Matter and Radiation at Extremes",

issn = "2468-080X",

publisher = "AIP Publishing",

number = "3",

}

Rodrigues, MD, Bonasera, A, Scisciò, M, Pérez-Hernández, JA, Ehret, M, Filippi, F, Andreoli, PL, Huault, M, Larreur, H, Singappuli, D, Molloy, D, Raffestin, D, Alonzo, M, Rapisarda, GG, Lattuada, D, Guardo, GL, Verona, C, Consoli, F, Petringa, G, McNamee, A, Cognata, ML, Palmerini, S, Carriere, T, Cipriani, M, Giorgio, GD, Cristofari, G, Angelis, RD, Cirrone, GAP, Margarone, D, Giuffrida, L, Batani, D, Nicolai, P, Batani, K, Lera, R, Luca, VOLPE, Giulietti, D, Agarwal, S, Krupka, M, Singh, S & Consoli, F 2024, 'Radioisotope production using lasers: From basic science to applications', Matter and Radiation at Extremes, vol. 9, no. 3, 037203. https://doi.org/10.1063/5.0196909

TY - JOUR

T1 - Radioisotope production using lasers: From basic science to applications

AU - Rodrigues, Marcia Dias

AU - Bonasera, Aldo

AU - Scisciò, M.

AU - Pérez-Hernández, J. A.

AU - Ehret, Michael

AU - Filippi, F.

AU - Andreoli, P. L.

AU - Huault, M.

AU - Larreur, H.

AU - Singappuli, D.

AU - Molloy, D.

AU - Raffestin, Didier

AU - Alonzo, M.

AU - Rapisarda, G. G.

AU - Lattuada, Dario

AU - Guardo, G. L.

AU - Verona, C.

AU - Consoli, Fe

AU - Petringa, Giada

AU - McNamee, A.

AU - Cognata, M. La

AU - Palmerini, S.

AU - Carriere, T.

AU - Cipriani, Mattia

AU - Giorgio, G. Di

AU - Cristofari, G.

AU - Angelis, Riccardo De

AU - Cirrone, G. A. P.

AU - Margarone, D.

AU - Giuffrida, Lorenzo

AU - Batani, Dimitri

AU - Nicolai, Philippe

AU - Batani, K.

AU - Lera, R.

AU - Luca, VOLPE

AU - Giulietti, D.

AU - Agarwal, S.

AU - Krupka, Michal

AU - Singh, S.

AU - Consoli, Fabrizio

PY - 2024/5/1

Y1 - 2024/5/1

N2 - The discovery of chirped pulse amplification has led to great improvements in laser technology, enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers. Protons with energies of tens of MeV can be accelerated using, for instance, target normal sheath acceleration and focused on secondary targets. Under such conditions, nuclear reactions can occur, with the production of radioisotopes suitable for medical application. The use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators. In this paper, we study the production of 67Cu, 63Zn, 18F, and 11C, which are currently used in positron emission tomography and other applications. At the same time, we study the reactions 10B(p,α)7Be and 70Zn(p,4n)67Ga to put further constraints on the proton distributions at different angles, as well as the reaction 11B(p,α)8Be relevant for energy production. The experiment was performed at the 1 PW laser facility at Vega III in Salamanca, Spain. Angular distributions of radioisotopes in the forward (with respect to the laser direction) and backward directions were measured using a high purity germanium detector. Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera [Nucl. Instrum. Methods Phys. Res., Sect. A 637, 164–170 (2011)].

AB - The discovery of chirped pulse amplification has led to great improvements in laser technology, enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few micrometers. Protons with energies of tens of MeV can be accelerated using, for instance, target normal sheath acceleration and focused on secondary targets. Under such conditions, nuclear reactions can occur, with the production of radioisotopes suitable for medical application. The use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on accelerators. In this paper, we study the production of 67Cu, 63Zn, 18F, and 11C, which are currently used in positron emission tomography and other applications. At the same time, we study the reactions 10B(p,α)7Be and 70Zn(p,4n)67Ga to put further constraints on the proton distributions at different angles, as well as the reaction 11B(p,α)8Be relevant for energy production. The experiment was performed at the 1 PW laser facility at Vega III in Salamanca, Spain. Angular distributions of radioisotopes in the forward (with respect to the laser direction) and backward directions were measured using a high purity germanium detector. Our results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera [Nucl. Instrum. Methods Phys. Res., Sect. A 637, 164–170 (2011)].

U2 - 10.1063/5.0196909

DO - 10.1063/5.0196909

M3 - Article

SN - 2468-080X

VL - 9

JO - Matter and Radiation at Extremes

JF - Matter and Radiation at Extremes

IS - 3

M1 - 037203

ER -

Radioisotope production using lasers: From basic science to applications

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