Abstract
The field of high atomic number nanoparticle radiosensitising agents is reviewed. After a brief discussion of the new mode of physicochemical action implied by irradiation of high atomic number nanoparticles embedded in biological systems, a series of exemplars are discussed. Silver-, gadolinium- and gold-based nanoparticles are discussed in order of increasing atomic number with functionalisation strategies being outlined. In vitro and in vivo evidence for radio-enhancement and the mechanisms attributed to the increased biological effect are discussed.
| Original language | English |
|---|---|
| Pages (from-to) | 593-603 |
| Number of pages | 11 |
| Journal | Clinical Oncology |
| Volume | 25 |
| Issue number | 10 |
| Early online date | 19 Jul 2013 |
| DOIs | |
| Publication status | Published - Oct 2013 |
Access to Document
- Radiosensitising Nanoparticles as Novel Cancer Therapeutics — Pipe Dream or Realistic Prospect?
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