Radiosensitising Nanoparticles as Novel Cancer Therapeutics — Pipe Dream or Realistic Prospect?

J. A. Coulter, W. B. Hyland, J. Nicol, F. J. Currell

Research output: Contribution to journalArticlepeer-review

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Abstract

The field of high atomic number nanoparticle radiosensitising agents is reviewed. After a brief discussion of the new mode of physicochemical action implied by irradiation of high atomic number nanoparticles embedded in biological systems, a series of exemplars are discussed. Silver-, gadolinium- and gold-based nanoparticles are discussed in order of increasing atomic number with functionalisation strategies being outlined. In vitro and in vivo evidence for radio-enhancement and the mechanisms attributed to the increased biological effect are discussed.
Original languageEnglish
Pages (from-to)593-603
Number of pages11
JournalClinical Oncology
Volume25
Issue number10
Early online date19 Jul 2013
DOIs
Publication statusPublished - Oct 2013

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