Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.
ASJC Scopus subject areas
- Physical and Theoretical Chemistry
- Organic Chemistry
Ravalico, F., Messina, I., Berberian, V., James, S., Migaud, M., & Vyle, J. (2011). Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill. Organic and Biomolecular Chemistry, 9(19), 6496-6497. https://doi.org/10.1039/c1ob06041d