Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

Francesco Ravalico, Ivano Messina, Victoria Berberian, Stuart James, Marie Migaud, Joseph Vyle

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)


Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.
Original languageEnglish
Pages (from-to)6496-6497
Number of pages2
JournalOrganic and Biomolecular Chemistry
Issue number19
Early online date20 Jul 2011
Publication statusPublished - 07 Oct 2011

ASJC Scopus subject areas

  • Physical and Theoretical Chemistry
  • Organic Chemistry
  • Biochemistry


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