Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

Francesco Ravalico; Ivano Messina; Victoria Berberian; Stuart James; Marie Migaud; Joseph Vyle

doi:10.1039/c1ob06041d

Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

Francesco Ravalico, Ivano Messina, Victoria Berberian, Stuart James, Marie Migaud, Joseph Vyle

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Abstract

Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.

Original language	English
Pages (from-to)	6496-6497
Number of pages	2
Journal	Organic and Biomolecular Chemistry
Volume	9
Issue number	19
Early online date	20 Jul 2011
DOIs	https://doi.org/10.1039/c1ob06041d
Publication status	Published - 07 Oct 2011

ASJC Scopus subject areas

Physical and Theoretical Chemistry
Organic Chemistry
Biochemistry

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title = "Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill",

abstract = "Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.",

author = "Francesco Ravalico and Ivano Messina and Victoria Berberian and Stuart James and Marie Migaud and Joseph Vyle",

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T1 - Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

AU - Ravalico, Francesco

AU - Messina, Ivano

AU - Berberian, Victoria

AU - James, Stuart

AU - Migaud, Marie

AU - Vyle, Joseph

PY - 2011/10/7

Y1 - 2011/10/7

N2 - Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.

AB - Using a ball mill, rapid, atom-economic coupling between adenosine-5'-phosphoromorpholidate and phosphorylated ribose derivatives as their sodium or barium salts was achieved. Facile purification by reversed-phase HPLC enabled product isolation within hours.

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DO - 10.1039/c1ob06041d

M3 - Article

SN - 1477-0520

VL - 9

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EP - 6497

JO - Organic and Biomolecular Chemistry

JF - Organic and Biomolecular Chemistry

IS - 19

ER -

Rapid synthesis of nucleotide pyrophosphate linkages in a ball mill

Abstract

ASJC Scopus subject areas

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