RAPTA complexes containing N-substituted Tetrazole scaffolds: Synthesis, characterization and Antiproliferative activity

Poulami Mandal, Novina Malviya, Bidyut Kumar Kundu, Sandeep Singh Dhankhar, C. M. Nagaraja, Suman Mukhopadhyay

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1 Citation (Scopus)

Abstract

This work describes the synthesis of a series of Ru(II)-Arene (Arene=p-cymene, benzene) complexes using different N-substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5- triaza-7-phospha-tricyclo-[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF-7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo-pharmacological conditions.
Original languageEnglish
Article numbere4179
Number of pages12
JournalApplied Organometallic Chemistry
Volume32
Issue number3
Early online date05 Dec 2017
DOIs
Publication statusPublished - 01 Mar 2018
Externally publishedYes

Keywords

  • RAPTA complexes
  • antiproliferative activity
  • stability study
  • tetrazole scaffolds

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