Abstract
This work describes the synthesis of a series of Ru(II)-Arene (Arene=p-cymene, benzene) complexes using different N-substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5- triaza-7-phospha-tricyclo-[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF-7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo-pharmacological conditions.
Original language | English |
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Article number | e4179 |
Number of pages | 12 |
Journal | Applied Organometallic Chemistry |
Volume | 32 |
Issue number | 3 |
Early online date | 05 Dec 2017 |
DOIs | |
Publication status | Published - 01 Mar 2018 |
Externally published | Yes |
Keywords
- RAPTA complexes
- antiproliferative activity
- stability study
- tetrazole scaffolds