RAPTA complexes containing N-substituted Tetrazole scaffolds: Synthesis, characterization and Antiproliferative activity

Poulami Mandal; Novina Malviya; Bidyut Kumar Kundu; Sandeep Singh Dhankhar; C. M. Nagaraja; Suman Mukhopadhyay

doi:10.1002/aoc.4179

RAPTA complexes containing N-substituted Tetrazole scaffolds: Synthesis, characterization and Antiproliferative activity

Poulami Mandal, Novina Malviya, Bidyut Kumar Kundu, Sandeep Singh Dhankhar, C. M. Nagaraja, Suman Mukhopadhyay

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Abstract

This work describes the synthesis of a series of Ru(II)-Arene (Arene=p-cymene, benzene) complexes using different N-substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5- triaza-7-phospha-tricyclo-[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF-7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo-pharmacological conditions.

Original language	English
Article number	e4179
Number of pages	12
Journal	Applied Organometallic Chemistry
Volume	32
Issue number	3
Early online date	05 Dec 2017
DOIs	https://doi.org/10.1002/aoc.4179
Publication status	Published - 01 Mar 2018
Externally published	Yes

Keywords

RAPTA complexes
antiproliferative activity
stability study
tetrazole scaffolds

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title = "RAPTA complexes containing N-substituted Tetrazole scaffolds: Synthesis, characterization and Antiproliferative activity",

abstract = "This work describes the synthesis of a series of Ru(II)-Arene (Arene=p-cymene, benzene) complexes using different N-substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5- triaza-7-phospha-tricyclo-[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF-7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo-pharmacological conditions.",

keywords = "RAPTA complexes, antiproliferative activity, stability study, tetrazole scaffolds",

author = "Poulami Mandal and Novina Malviya and Kundu, {Bidyut Kumar} and Dhankhar, {Sandeep Singh} and Nagaraja, {C. M.} and Suman Mukhopadhyay",

year = "2018",

month = mar,

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doi = "10.1002/aoc.4179",

language = "English",

volume = "32",

journal = "Applied Organometallic Chemistry",

issn = "0268-2605",

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RAPTA complexes containing N-substituted Tetrazole scaffolds: Synthesis, characterization and Antiproliferative activity. / Mandal, Poulami; Malviya, Novina; Kundu, Bidyut Kumar; Dhankhar, Sandeep Singh; Nagaraja, C. M.; Mukhopadhyay, Suman.

In: Applied Organometallic Chemistry, Vol. 32, No. 3, e4179, 01.03.2018.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - RAPTA complexes containing N-substituted Tetrazole scaffolds: Synthesis, characterization and Antiproliferative activity

AU - Mandal, Poulami

AU - Malviya, Novina

AU - Kundu, Bidyut Kumar

AU - Dhankhar, Sandeep Singh

AU - Nagaraja, C. M.

AU - Mukhopadhyay, Suman

PY - 2018/3/1

Y1 - 2018/3/1

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AB - This work describes the synthesis of a series of Ru(II)-Arene (Arene=p-cymene, benzene) complexes using different N-substituted tetrazole ligands and their PTA analogues. All the complexes have been characterized thoroughly using different analytical techniques. Antiproliferative activity of the synthesized complexes against different cell lines indicates remarkable activity of certain complexes up to nanomolar level. In few cases introduction of water soluble PTA (PTA = 1,3,5- triaza-7-phospha-tricyclo-[3.3.1.1]decane) ligand induce significant cytotoxic activity in the ruthenium complex with respect to their chloro analogues, particularly against Jurkat and MCF-7 cell lines. Interaction with different biomolecules and stability of the RAPTA complexes have been explored in pseudo-pharmacological conditions.

KW - RAPTA complexes

KW - antiproliferative activity

KW - stability study

KW - tetrazole scaffolds

U2 - 10.1002/aoc.4179

DO - 10.1002/aoc.4179

M3 - Article

VL - 32

JO - Applied Organometallic Chemistry

JF - Applied Organometallic Chemistry

SN - 0268-2605

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ER -