Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

Stella Kouloulia; Erik I. Hallin; Konstanze Simbriger; Inês S. Amorim; Gilliard Lach; Theoklitos Amvrosiadis; Kleanthi Chalkiadaki; Agniete Kampaite; Vinh Tai Truong; Mehdi Hooshmandi; Seyed Mehdi Jafarnejad; Paul Skehel; Petri Kursula; Arkady Khoutorsky; Christos G. Gkogkas

doi:10.1016/j.celrep.2019.11.023

Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

Stella Kouloulia, Erik I. Hallin, Konstanze Simbriger, Inês S. Amorim, Gilliard Lach, Theoklitos Amvrosiadis, Kleanthi Chalkiadaki, Agniete Kampaite, Vinh Tai Truong, Mehdi Hooshmandi, Seyed Mehdi Jafarnejad, Paul Skehel, Petri Kursula, Arkady Khoutorsky, Christos G. Gkogkas

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Abstract

Kouloulia et al. demonstrate that, during early postnatal brain development, deamidation of the translation initiation factor 4E-BP2 renders it susceptible to ubiquitination and proteasomal degradation via enhanced binding to the Raptor-CUL4B complex. mTORC1 or glutamate receptor inhibition stabilizes deamidated 4E-BP2. Moreover, deamidated 4E-BP2 regulates the translation of specific mRNAs and NF-κB activity.

Original language	English
Pages (from-to)	3620-3635.e7
Journal	Cell Reports
Volume	29
Issue number	11
DOIs	https://doi.org/10.1016/j.celrep.2019.11.023
Publication status	Published - 10 Dec 2019

Keywords

4E-BP2
CUL4B
NF-κB
Raptor
asparagine deamidation
mTORC1
postnatal brain
proteasome
translational control

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10.1016/j.celrep.2019.11.023Licence: CC BY

Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity
© 2019 The Author(s). This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 5.56 MBLicence: CC BY

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Kouloulia, S., Hallin, E. I., Simbriger, K., Amorim, I. S., Lach, G., Amvrosiadis, T., Chalkiadaki, K., Kampaite, A., Truong, V. T., Hooshmandi, M., Jafarnejad, S. M., Skehel, P., Kursula, P., Khoutorsky, A., & Gkogkas, C. G. (2019). Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity. Cell Reports, 29(11), 3620-3635.e7. https://doi.org/10.1016/j.celrep.2019.11.023

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abstract = "Kouloulia et al. demonstrate that, during early postnatal brain development, deamidation of the translation initiation factor 4E-BP2 renders it susceptible to ubiquitination and proteasomal degradation via enhanced binding to the Raptor-CUL4B complex. mTORC1 or glutamate receptor inhibition stabilizes deamidated 4E-BP2. Moreover, deamidated 4E-BP2 regulates the translation of specific mRNAs and NF-κB activity.",

keywords = "4E-BP2, CUL4B, NF-κB, Raptor, asparagine deamidation, mTORC1, postnatal brain, proteasome, translational control",

author = "Stella Kouloulia and Hallin, {Erik I.} and Konstanze Simbriger and Amorim, {In{\^e}s S.} and Gilliard Lach and Theoklitos Amvrosiadis and Kleanthi Chalkiadaki and Agniete Kampaite and Truong, {Vinh Tai} and Mehdi Hooshmandi and Jafarnejad, {Seyed Mehdi} and Paul Skehel and Petri Kursula and Arkady Khoutorsky and Gkogkas, {Christos G.}",

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doi = "10.1016/j.celrep.2019.11.023",

language = "English",

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Kouloulia, S, Hallin, EI, Simbriger, K, Amorim, IS, Lach, G, Amvrosiadis, T, Chalkiadaki, K, Kampaite, A, Truong, VT, Hooshmandi, M, Jafarnejad, SM, Skehel, P, Kursula, P, Khoutorsky, A & Gkogkas, CG 2019, 'Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity', Cell Reports, vol. 29, no. 11, pp. 3620-3635.e7. https://doi.org/10.1016/j.celrep.2019.11.023

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T1 - Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

AU - Kouloulia, Stella

AU - Hallin, Erik I.

AU - Simbriger, Konstanze

AU - Amorim, Inês S.

AU - Lach, Gilliard

AU - Amvrosiadis, Theoklitos

AU - Chalkiadaki, Kleanthi

AU - Kampaite, Agniete

AU - Truong, Vinh Tai

AU - Hooshmandi, Mehdi

AU - Jafarnejad, Seyed Mehdi

AU - Skehel, Paul

AU - Kursula, Petri

AU - Khoutorsky, Arkady

AU - Gkogkas, Christos G.

PY - 2019/12/10

Y1 - 2019/12/10

N2 - Kouloulia et al. demonstrate that, during early postnatal brain development, deamidation of the translation initiation factor 4E-BP2 renders it susceptible to ubiquitination and proteasomal degradation via enhanced binding to the Raptor-CUL4B complex. mTORC1 or glutamate receptor inhibition stabilizes deamidated 4E-BP2. Moreover, deamidated 4E-BP2 regulates the translation of specific mRNAs and NF-κB activity.

AB - Kouloulia et al. demonstrate that, during early postnatal brain development, deamidation of the translation initiation factor 4E-BP2 renders it susceptible to ubiquitination and proteasomal degradation via enhanced binding to the Raptor-CUL4B complex. mTORC1 or glutamate receptor inhibition stabilizes deamidated 4E-BP2. Moreover, deamidated 4E-BP2 regulates the translation of specific mRNAs and NF-κB activity.

KW - 4E-BP2

KW - CUL4B

KW - NF-κB

KW - Raptor

KW - asparagine deamidation

KW - mTORC1

KW - postnatal brain

KW - proteasome

KW - translational control

UR - http://www.mendeley.com/catalogue/raptormediated-proteasomal-degradation-deamidated-4ebp2-regulates-postnatal-neuronal-translation-nf%CE%BA

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DO - 10.1016/j.celrep.2019.11.023

M3 - Article

C2 - 31825840

VL - 29

SP - 3620-3635.e7

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 11

ER -

Raptor-Mediated Proteasomal Degradation of Deamidated 4E-BP2 Regulates Postnatal Neuronal Translation and NF-κB Activity

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