Rational Design of New Cyclic Analogues of the Antimicrobial Lipopeptide Tridecaptin A1

Ross Ballantine, Yong-Xin Li, Pei-Yuan Qian, Stephen Cochrane

Research output: Contribution to journalArticle

7 Citations (Scopus)
155 Downloads (Pure)

Abstract

Non-ribosomal peptides (NRPs) are a rich source of antibiotic candidates. However, it was recently discovered that resistance to NRPs can be mediated by D-stereoselective peptidases. The tridecaptins, a class of NRPs that selectively target Gram-negative bacteria, are degraded by the D-peptidase TriF. Through analysis of a solution NMR structure of tridecaptin A1, we have rationally synthesized new cyclic tridecaptin analogues that retain strong antimicrobial activity and are resistant to TriF.
Original languageEnglish
Pages (from-to)1-4
JournalChemical Communications
Early online date04 Sep 2018
DOIs
Publication statusEarly online date - 04 Sep 2018

Fingerprint Dive into the research topics of 'Rational Design of New Cyclic Analogues of the Antimicrobial Lipopeptide Tridecaptin A1'. Together they form a unique fingerprint.

  • Cite this