Non-ribosomal peptides (NRPs) are a rich source of antibiotic candidates. However, it was recently discovered that resistance to NRPs can be mediated by D-stereoselective peptidases. The tridecaptins, a class of NRPs that selectively target Gram-negative bacteria, are degraded by the D-peptidase TriF. Through analysis of a solution NMR structure of tridecaptin A1, we have rationally synthesized new cyclic tridecaptin analogues that retain strong antimicrobial activity and are resistant to TriF.
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Structural and mechanistic studies on antimicrobial peptides that target multi-drug resistant bacteriaAuthor: Ballantine, R., Jul 2021
Student thesis: Doctoral Thesis › Doctor of Philosophy