Re-exploration of the PHCCC Scaffold: Discovery of Improved Positive Allosteric Modulators of mGluR4

Richard Williams, Y. Zhou, C.M. Niswender, Q. Luo, P.J. Conn, C.W. Lindsley, C.R. Hopkins

Research output: Contribution to journalArticlepeer-review

42 Citations (Scopus)

Abstract

This paper describes a detailed structure activity relationship (SAR) analysis of the metabotropic glutamate receptor 4 (mGluR4) positive allosteric modulator, (-)-N-phenyl-7-(hydroxyimino)cyclopropa[b]-chromen-la-carboxamide (PHCCC). We have now developed compounds with improved potency and efficacy; in addition, compounds are presented that show selectivity for mGluR4 versus the other mGluR subtypes.
Original languageEnglish
Pages (from-to)411-419
Number of pages9
JournalACS chemical neuroscience
Volume1
Issue number6
DOIs
Publication statusPublished - 16 Jun 2010

ASJC Scopus subject areas

  • Biochemistry
  • Cell Biology
  • Physiology
  • Cognitive Neuroscience

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