Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism

A. Comby; E. Bloch; C. M.M. Bond; D. Descamps; J. Miles; S. Petit; S. Rozen; J. B. Greenwood; V. Blanchet; Y. Mairesse

doi:10.1038/s41467-018-07609-9

Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism

A. Comby, E. Bloch, C. M.M. Bond, D. Descamps, J. Miles, S. Petit, S. Rozen, J. B. Greenwood, V. Blanchet, Y. Mairesse^*

^*Corresponding author for this work

School of Mathematics and Physics

Research output: Contribution to journal › Article › peer-review

20 Citations (Scopus)

232 Downloads (Pure)

Abstract

The fast and accurate analysis of chiral chemical mixtures is crucial for many applications but remains challenging. Here we use elliptically-polarized femtosecond laser pulses at high repetition rates to photoionize chiral molecules. The 3D photoelectron angular distribution produced provides molecular fingerprints, showing a strong forward-backward asymmetry which depends sensitively on the molecular structure and degree of ellipticity. Continuously scanning the laser ellipticity and analyzing the evolution of the rich, multi-dimensional molecular signatures allows us to observe real-time changes in the chemical and chiral content present with unprecedented speed and accuracy. We measure the enantiomeric excess of a compound with an accuracy of 0.4% in 10 min acquisition time, and follow the evolution of a mixture with an accuracy of 5% with a temporal resolution of 3 s. This method is even able to distinguish isomers, which cannot be easily distinguished by mass-spectrometry.

Original language	English
Article number	5212
Journal	Nature Communications
Volume	9
Issue number	1
DOIs	https://doi.org/10.1038/s41467-018-07609-9
Publication status	Published - 01 Dec 2018

ASJC Scopus subject areas

Chemistry(all)
Biochemistry, Genetics and Molecular Biology(all)
Physics and Astronomy(all)

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Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism
Copyright 2018 the authors. This is an open access article published under a Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
Final published version, 6.29 MBLicence: CC BY

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Jason Greenwood
- J.Greenwood@qub.ac.uk
- School of Mathematics and Physics - Reader
- Centre for Plasma Physics (CPP)
Person: Academic

Cite this

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title = "Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism",

abstract = "The fast and accurate analysis of chiral chemical mixtures is crucial for many applications but remains challenging. Here we use elliptically-polarized femtosecond laser pulses at high repetition rates to photoionize chiral molecules. The 3D photoelectron angular distribution produced provides molecular fingerprints, showing a strong forward-backward asymmetry which depends sensitively on the molecular structure and degree of ellipticity. Continuously scanning the laser ellipticity and analyzing the evolution of the rich, multi-dimensional molecular signatures allows us to observe real-time changes in the chemical and chiral content present with unprecedented speed and accuracy. We measure the enantiomeric excess of a compound with an accuracy of 0.4% in 10 min acquisition time, and follow the evolution of a mixture with an accuracy of 5% with a temporal resolution of 3 s. This method is even able to distinguish isomers, which cannot be easily distinguished by mass-spectrometry.",

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T1 - Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism

AU - Comby, A.

AU - Bloch, E.

AU - Bond, C. M.M.

AU - Descamps, D.

AU - Miles, J.

AU - Petit, S.

AU - Rozen, S.

AU - Greenwood, J. B.

AU - Blanchet, V.

AU - Mairesse, Y.

PY - 2018/12/1

Y1 - 2018/12/1

N2 - The fast and accurate analysis of chiral chemical mixtures is crucial for many applications but remains challenging. Here we use elliptically-polarized femtosecond laser pulses at high repetition rates to photoionize chiral molecules. The 3D photoelectron angular distribution produced provides molecular fingerprints, showing a strong forward-backward asymmetry which depends sensitively on the molecular structure and degree of ellipticity. Continuously scanning the laser ellipticity and analyzing the evolution of the rich, multi-dimensional molecular signatures allows us to observe real-time changes in the chemical and chiral content present with unprecedented speed and accuracy. We measure the enantiomeric excess of a compound with an accuracy of 0.4% in 10 min acquisition time, and follow the evolution of a mixture with an accuracy of 5% with a temporal resolution of 3 s. This method is even able to distinguish isomers, which cannot be easily distinguished by mass-spectrometry.

AB - The fast and accurate analysis of chiral chemical mixtures is crucial for many applications but remains challenging. Here we use elliptically-polarized femtosecond laser pulses at high repetition rates to photoionize chiral molecules. The 3D photoelectron angular distribution produced provides molecular fingerprints, showing a strong forward-backward asymmetry which depends sensitively on the molecular structure and degree of ellipticity. Continuously scanning the laser ellipticity and analyzing the evolution of the rich, multi-dimensional molecular signatures allows us to observe real-time changes in the chemical and chiral content present with unprecedented speed and accuracy. We measure the enantiomeric excess of a compound with an accuracy of 0.4% in 10 min acquisition time, and follow the evolution of a mixture with an accuracy of 5% with a temporal resolution of 3 s. This method is even able to distinguish isomers, which cannot be easily distinguished by mass-spectrometry.

U2 - 10.1038/s41467-018-07609-9

DO - 10.1038/s41467-018-07609-9

M3 - Article

AN - SCOPUS:85058029551

VL - 9

JO - Nature Communications

JF - Nature Communications

SN - 2041-1723

IS - 1

M1 - 5212

ER -

Real-time determination of enantiomeric and isomeric content using photoelectron elliptical dichroism

Abstract

ASJC Scopus subject areas

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Jason Greenwood

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