A dynamic model was adopted to analyze the impact of the occupancy level in a generic bus on the air conditioning (AC) performance, under different control strategies. The dynamic model was built up by coupling two sub-models of an AC system and the cabin, using MATLAB and Simscape toolbox (R2019a). The AC system has two units, which are controlled independently and based on a Vapour Compression Cycle (VCC). The cabin is modelled by means of moisture air networks, exchanging heat with the refrigerant through the evaporator/condenser of the AC units. Five different strategies were investigated for a range of occupancy levels from 5 to 70 people on board. Results show the links between the occupancy level, power, and discomfort level with the implemented control strategies. As the results suggest, adopting a multi-unit AC system would be more advantageous than using a single unit in terms of the discomfort level and power requirement.